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Merck
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Key Documents

C0867

Sigma-Aldrich

Anti-CRTH2 (GRP44) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-Chemoattractant Receptor-homologous Molecule expressed on TH2 Cells, Anti-Putative G-Protein Coupled Receptor 44

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About This Item

Numéro MDL:
MFCD08064414
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

200

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~43 kDa by calculation

Espèces réactives

rat, mouse, human

Technique(s)

western blot: 1:500-1:1,000 using CRTH2-transfected Jurkat cells

Conditions d'expédition

dry ice

Température de stockage

−20°C

Informations sur le gène

human ... GPR44(11251)
mouse ... Gpr44(14764)
rat ... Gpr44(309212)

Catégories apparentées

Immunogène

peptide corresponding to the human CRTH2 (GRP44) protein, near the C-terminus (amino acids 329-348).

Application

Anti-CRTH2 (GRP44) antibody produced in rabbit is suitable for western blotting at a working dilution of 1:500-1:1,000 using CRTH2- transfected Jurkat cells.

Actions biochimiques/physiologiques

CRTH2 (chemoattractant receptor-homologous molecule), is known as the putative G protein-coupled receptor (GP44), is expressed on T helper 2 (Th2) cells. It is also referred as DP2, DL1R and CD294. It′s a human protein and belongs to G protein-coupled leukocyte chemo attractant receptor family. It is not expressed on human amniocytes or myocytes. On activation of CRTH2, PGD(2) induces human osteoclast apoptosis and the apoptosis intrinsic pathway. CRTH2, CD4 and T cells all together may be involved in the pathogenesis of IgG4-related Lacrimal gland enlargement (LGE) causing Mikulicz′s disease (MD).

Forme physique

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Yukari Saito et al.
International archives of allergy and immunology, 158 Suppl 1, 42-46 (2012-06-01)
Lacrimal gland enlargement (LGE) is one of the characteristics of Mikulicz's disease (MD). Recently, marked serum immunoglobulin (Ig)G4 elevation and infiltration of IgG4-positive plasma cells in the enlarged exocrine glands have been reported in MD patients. Moreover, we have reported
Li Yue et al.
Bone, 51(3), 338-346 (2012-06-19)
Prostaglandin D(2) (PGD(2)) is a lipid mediator synthesized from arachidonic acid that directly activates two specific receptors, the D-type prostanoid (DP) receptor and chemoattractant receptor homologous molecule expressed on T-helper type 2 cells (CRTH2). PGD(2) can affect bone metabolism by
Lynne Sykes et al.
PloS one, 7(11), e50734-e50734 (2012-12-12)
15-deoxy-Δ 12,14- Prostaglandin J2 (15dPGJ2) inhibits Nuclear factor kappa B (NF-κB) in human myocytes and amniocytes and delays inflammation induced preterm labour in the mouse. 15dPGJ2 is a ligand for the Chemoattractant Receptor Homologous to the T helper 2 cell

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