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Key Documents

A9272

Sigma-Aldrich

Adenosine 3′-monophosphate

from yeast

Synonyme(s) :

3′-AMP, 3′-Adenylic acid

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About This Item

Formule empirique (notation de Hill):
C10H14N5O7P
Numéro CAS:
Poids moléculaire :
347.22
Numéro Beilstein :
54478
Numéro CE :
Numéro MDL:
Code UNSPSC :
41106305
eCl@ss :
32160414
ID de substance PubChem :
Nomenclature NACRES :
NA.51

Source biologique

yeast

Pureté

≥98% (HPLC)

Forme

powder

Solubilité

1 N NH4OH: 50 mg/mL, clear, colorless

Température de stockage

−20°C

Chaîne SMILES 

Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](OP(O)(O)=O)[C@H]3O

InChI

1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(17)7(4(1-16)21-10)22-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

Clé InChI

LNQVTSROQXJCDD-KQYNXXCUSA-N

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Application

Adenosine 3′-monophosphate (3′-AMP) is a metabolite produced from hydrolysis of 2′,3′-cAMP by a family of metal-dependent phosphodiesterases. 3′-AMP inhibits proliferation of preglomerular vascular smooth muscle cells and glomerular mesangial cells via A2B receptors. 2′,3′-cAMP and 3′-AMP represent a new unexplored pathway for adenosine-based cell regulation.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)


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Chun Yuan et al.
Molecular medicine reports, 16(4), 4529-4536 (2017-08-30)
Bone fracture healing is a complex process, which is associated with several factors, including age and osteoporosis. Certain genes and biological processes that may contribute to fracture healing, have been identified following developments in systems biology and molecular biology technologies
Yuyuan Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(32), 11612-11617 (2014-07-30)
During the early evolution of life, 8-oxo-7,8-dihydro-2'-deoxyguanosine (O) may have functioned as a proto-flavin capable of repairing cyclobutane pyrimidine dimers in DNA or RNA by photoinduced electron transfer using longer wavelength UVB radiation. To investigate the ability of O to
Sumit Bansal et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1011, 171-178 (2016-01-17)
Detoxification of lithocholic acid (LCA) to lithocholic acid sulfate (LCA-S) is catalyzed by sulfotransferases, mainly SULT2A1. We developed and validated an ultra-high performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method to quantify human liver cytosolic-dependent LCA sulfation. Chromatographic separation was achieved
Aksorn Saengtienchai et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 214, 28-35 (2018-09-04)
There have been many reports regarding toxic chemicals in birds. Chemicals are mainly metabolized in the liver through phase I oxidation by cytochrome P450 (CYP) and phase II conjugation by conjugated enzymes, such as UDP-glucuronosyltransferase (UGT), sulfotransferase (SULT), glutathione-S-transferase (GST)
Yang Yang et al.
Oncotarget, 8(25), 40289-40304 (2017-02-09)
Resveratrol (RV) is a natural polyphenol compound with a wide range of activities, including inhibition of human bladder cancer (HBC) cell growth. Because RV is rapidly metabolized and has poor bioavailability, it is unclear whether the antitumor activity is due

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