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Key Documents

A7785

Sigma-Aldrich

Apolipoprotein C-I from human plasma

≥95% (SDS-PAGE), lyophilized powder

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About This Item

Numéro CAS:
2235444-72-9
Numéro MDL:
MFCD00162928
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77

Source biologique

human

Niveau de qualité

200

Pureté

≥95% (SDS-PAGE)

Forme

lyophilized powder

Poids mol.

average mol wt 6.6 kDa

Technique(s)

inhibition assay: suitable

Numéro d'accès UniProt

P02654

Température de stockage

−20°C

Informations sur le gène

human ... APOC1(341)

Description générale

Very low density lipoprotein.

Application

Apolipoprotein C-1 directly interferes with fatty acid uptake and is a major plasma inhibitor of cholesterol ester transfer protein. Apolipoprotein C-I has been used to develop a quantitative strategy, named secretome-derived isotopic tag (SDIT), to concurrently identify and quantify the adipocyte-secreted plasma proteins from normal and high-fat-diet (HFD) induced obese mice.

Actions biochimiques/physiologiques

Interferes directly with fatty acid uptake and is the major plasma inhibitor of cholesterol ester transfer protein.

Forme physique

Lyophilized from 10 mM NH4HCO3, pH 7.5

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

B S Suri et al.
The Biochemical journal, 178(2), 455-466 (1979-02-15)
1. The work reported was designed to provide quantitative information about the capacity of the extrahepatic tissues of the rat to degrade injected VLD lipoproteins (very-low-density lipoproteins, d less than 1.006) to LD lipoproteins (low-density lipoproteins, d 1.006--1.063) and to
Rong-Xia Li et al.
Journal of proteome research, 11(5), 2851-2862 (2012-03-13)
We developed a quantitative strategy, named secretome-derived isotopic tag (SDIT), to concurrently identify and quantify the adipocyte-secreted plasma proteins from normal and high-fat-diet (HFD) induced obese mice, based on the application of isotope-labeled secreted proteins from cultured mouse adipocytes as
Nathan L Meyers et al.
Biochemistry, 51(6), 1238-1248 (2012-01-24)
Apolipoprotein C-I (apoC-I) is an important constituent of high-density lipoprotein (HDL) and is involved in the accumulation of cholesterol ester in nascent HDL via inhibition of cholesterol ester transfer protein and potential activation of lecithin:cholesterol acyltransferase (LCAT). As the smallest

Articles

Cholesterol Transport

Since cholesterol is a water-insoluble molecule it must be packaged for transport within the plasma. The particles that package cholesterol, cholesteryl esters, and triglycerides for transport, are called lipoproteins.

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