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Key Documents

A5843

Sigma-Aldrich

Albumine from human serum

lyophilized powder, low endotoxin

Synonyme(s) :

HSA

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About This Item

Numéro CAS:
Numéro CE :
Numéro MDL:
Code UNSPSC :
12352202
eCl@ss :
42010201
Nomenclature NACRES :
NA.25

Source biologique

human

Niveau de qualité

Pureté

≥96% (agarose gel electrophoresis)

Forme

lyophilized powder

Poids mol.

monomer calculated mol wt 66478 Da

Impuretés

HIV I and HIVII, HCV and HBsAg, tested negative
≤1.0 EU/mg endotoxin

Solubilité

H2O: soluble 50 mg/mL

Numéro d'accès UniProt

Température de stockage

2-8°C

InChI

1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11

Clé InChI

QYSGYZVSCZSLHT-UHFFFAOYSA-N

Informations sur le gène

human ... ALB(213)

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Description générale

Albumin is the most copious protein in blood plasma. Liver produces human albumin.

Application

Albumin was used to test its effect on the in vitro bactericidal activity of cefditoren against penicillin-resistant Streptococcus pneumonia. It has been clinically used in serious and often life-threatening conditions, such as shock and blood loss due to trauma, burns, and surgery.
Albumin was used to study albumin-induced apoptosis in proximal tubule cells. It was also used in cell adhesion molecules and surface treatment studies.

Actions biochimiques/physiologiques

L′albumine sérique fonctionne en tant que protéine porteuse des stéroïdes, acides gras et hormones thyroïdes, et est essentielle à la régulation de la pression colloïde osmotique du sang. L′albumine est également capable de se lier à certaines substances exogènes, en particulier les médicaments (p. ex., ibuprofène, warfarine) et influence fortement leurs propriétés pharmacocinétiques. Le stress oxydant, qui entraîne des changements de l′état d′oxydoréduction de l′albumine, exerce des effets divers sur sa fonction physiologique.
Serum albumin functions as a carrier protein for steroids, fatty acids, and thyroid hormones, and is vital in regulating the colloidal osmotic pressures of blood. Albumin is also seen to bind to exogenous substances, particularly drugs (e.g., ibuprofen, warfarin), and strongly influences their pharmacokinetics. Oxidative stress leading to changes in the redox state of albumin has varied effects on its physiological function.

Autres remarques

Obtenir de plus amples informations sur l′albumine sérique humaine.

Clause de non-responsabilité

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves


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Consulter la Bibliothèque de documents

Sam Coffey et al.
PloS one, 10(10), e0140417-e0140417 (2015-10-16)
Diabetes mellitus (DM) has become an epidemic, causing a significant decline in quality of life of individuals due to its multisystem involvement. Kidney is an important target organ in DM accounting for the majority of patients requiring renal replacement therapy
Edina Korça et al.
Scientific reports, 10(1), 17105-17105 (2020-10-15)
Advanced glycation endproducts (AGEs) are formed in a series of non-enzymatic reactions between reducing sugars and the amino groups of proteins and accumulate during aging, diabetes mellitus, chronic kidney disease and other chronic diseases. Accumulation of AGE-modifications alters protein structure
Yasutaka Kuroda et al.
The Journal of toxicological sciences, 45(6), 327-337 (2020-06-05)
Hydrolyzed wheat proteins (HWPs) contained in cosmetics have occasionally caused immediate-type hypersensitivity following repeated skin exposure. Although the Cosmetic Ingredient Review Expert Panel concluded that < 3,500 Da HWP is safe for use in cosmetics, it remains biologically unknown how
Miranda J Ridder et al.
Infection and immunity, 88(8) (2020-06-10)
Staphylococcus aureus fatty acid kinase FakA is necessary for the incorporation of exogenous fatty acids into the lipid membrane. We previously demonstrated that the inactivation of fakA leads to decreased α-hemolysin (Hla) production but increased expression of the proteases SspAB
Nitin Agrawal et al.
Lab on a chip, 8(12), 2054-2061 (2008-11-22)
Neutrophil directional migration in response to chemical gradients, also known as chemotaxis, is one of the key phenomena in the immune responses against bacterial infection. To better study neutrophils chemotaxis, several in vitro assays have been developed that replicate chemotactic

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