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A3734

Sigma-Aldrich

1-Azakenpaullone

≥97% (HPLC)

Synonyme(s) :

9-Bromo-7,12-dihydro-pyrido[3′,2′:2,3]azepino[4,5-b]indol-6(5H)-one

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About This Item

Formule empirique (notation de Hill):
C15H10BrN3O
Numéro CAS:
676596-65-9
Poids moléculaire :
328.16
Numéro MDL:
MFCD09037522
Code UNSPSC :
12352200
ID de substance PubChem :
329770845
Nomenclature NACRES :
NA.77

Pureté

≥97% (HPLC)

Forme

powder

Conditions de stockage

protect from light

Couleur

gray-brown

Solubilité

DMSO: >10 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

O=C1CC2=C(NC3=C2C=C(Br)C=C3)C4=C(C=CC=N4)N1

InChI

1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)

Clé InChI

NTSBZVCEIVPKBJ-UHFFFAOYSA-N

Actions biochimiques/physiologiques

1-Azakenpaullone (AZP) can stimulate the transcription of β-catenin-related genes. This compound can induce the multiplication and replication of β cell.
1-Azakenpaullone is a cell permeable, potent, selective inhibitor of glycogen synthase kinase 3β (GSK3β) with 100-fold less cross-reactivity against CDKs. 1-Azakenpaullone can be used together with BIO and CHIR99021 as "gold standards" for GSK3 inhibition.

Attention

air sensitive

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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