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Principaux documents

484R-1

Sigma-Aldrich

PRAME (EP461) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

Preferentially-expressed Antigen in Melanoma

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About This Item

Code UNSPSC :
12352203

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP461, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (484R-14)
vial of 0.1 mL concentrate Research Use Only (484R-14-RUO)
vial of 0.5 mL concentrate (484R-15)
vial of 1.0 mL concentrate (484R-16)
vial of 1.0 mL concentrate Research Use Only (484R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (484R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (484R-17)
vial of 25.0 mL pre-dilute ready-to-use Research Use Only (484R-10-RUO)
vial of 25.0 mL pre-dilute ready-to-use (484R-10)
vial of 7.0 mL pre-dilute ready-to-use (484R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (484R-18-RUO)

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 (concentrated)

Isotype

IgG

Contrôle

melanoma

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

nuclear

Catégories apparentées

Description générale

PRAME (PReferentially-expressed Antigen in MElanoma) is a gene encoded on the 22q11-22 chromosomal sequence and encodes a 509 amino acid residue protein.1 PRAME is a melanoma antigen that is preferentially expressed in tumors and is recognized by cytotoxic T lymphocytes.2,3 PRAME can be used to distinguish between malignant melanoma cells and nevus cells,4 and therefore may be useful for diagnostic purposes to support a suspected case of melanoma. PRAME is considered a cancer-testis antigen (CTA)5 and is not strongly expressed in most other normal tissues. PRAME is positively expressed in about half of uveal melanomas,6 and the majority of mucosal melanomas.7

Qualité

  • United States - IVD
  • Canada - RUO
  • European Union - IVD
  • Japan - RUO

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and < 0.1% Sodium Azide.

Notes préparatoires

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Autres remarques

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Aimi Toyama et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(12), 1727-1733 (2019-08-04)
Mucosal melanomas are rare, and less is known about the biomarkers of this subtype in comparison to cutaneous or uveal melanomas. Preferentially expressed antigen in melanoma (PRAME) has been studied as a tool for prognostication of uveal melanomas, and immunotherapy
Frances Wadelin et al.
Molecular cancer, 9, 226-226 (2010-08-31)
PRAME/MAPE/OIP4 is a germinal tissue-specific gene that is also expressed at high levels in haematological malignancies and solid tumours. The physiological functions of PRAME in normal and tumour cells are unknown, although a role in the regulation of retinoic acid
Wa Zhang et al.
Oncotarget, 7(29), 45352-45369 (2016-06-21)
PRAME is a cancer-testis antigen (CTA) and potential immuno-therapeutic target, but has not been well-studied in epithelial ovarian cancer (EOC) or its high grade serous (HGSC) subtype. Compared to normal ovary, PRAME expression was significantly increased most EOC, regardless of

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