370R-1

LMO2 (SP51) Rabbit Monoclonal Antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100; 500
• Conjugué: unconjugated
• Forme d'anticorps: culture supernatant
• Type de produit anticorps: primary antibodies
• Clone: SP51, monoclonal
• Description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Forme: buffered aqueous solution
• Espèces réactives: human
• Conditionnement: vial of 0.1 mL concentrate (370R-14); vial of 0.5 mL concentrate (370R-15); bottle of 1.0 mL predilute (370R-17); vial of 1.0 mL concentrate (370R-16); bottle of 7.0 mL predilute (370R-18)
• Fabricant/nom de marque: Cell Marque^™
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500-1:2000
• Isotype: IgG
• Contrôle: diffuse large B-cell, follicular lymphoma
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Visualisation: nuclear
• Informations sur le gène: human ... LMO2(4005)

Description

Description générale

LMO2 is expressed in normal germinal center B-cells and in a subset of lymphomas derived from those cells in addition to bone marrow hematopoietic precursors and endothelial cells. LMO2 protein expression has also been shown to play an important role in the diagnosis of diffuse large B-cell lymphomas, regardless of rituximab treatment. It also plays a role in angiogenesis and hematopoiesis. It is weakly expressed in mantle zone B-cells but not in mantle cell or marginal zone lymphomas. SF Younes et al. Have demonstrated LMO2 expression in 70% of follicular lymphomas. These data suggest that anti-LMO2 is a useful adjunct in the diagnosis of follicular lymphoma (FL). As LMO2 appears not to be down regulated in higher grade FL or the interfollicular and diffuse components of FL, its utility in variant immunoarchitectural patterns of FL and in cases that lack CD10 and bcl2, is similar to that of HGAL. One advantage of LMO2 is its crisp nuclear localization that allows for easier interpretation than diffuse cytoplasmic staining pattern.

Qualité

IVD

IVD

IVD

RUO

Liaison

LMO2 Positive Control Slides, Product No. 370S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable