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Key Documents

356R-1

Sigma-Aldrich

Cytokeratin 5 & 6 (EP24 & EP67) Rabbit Monoclonal Primary Antibody

Synonyme(s) :

CK 5/6, cytokeratin 5/6

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

EP24 & EP67, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (356R-14)
vial of 0.1 mL concentrate Research Use Only (356R-14-RUO)
vial of 0.5 mL concentrate (356R-15)
vial of 1.0 mL concentrate (356R-16)
vial of 1.0 mL concentrate Research Use Only (356R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (356R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (356R-17)
vial of 7.0 mL pre-dilute ready-to-use (356R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (356R-18-RUO)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

Contrôle

mesothelioma, prostate, squamous cell carcinoma ((lung))

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic

Informations sur le gène

human ... KRT5(3852)

Catégories apparentées

Description générale

Twenty identified cytokeratins make up a complex family of intermediate filaments.1 Cytokeratin 5 (58kDa) & cytokeratin 6 (56kDa) are type II high molecular weight keratins that are expressed in a broad range of normal tissues including breast, prostate, mesothelium, skin and esophagus.1-3 Anti-Cytokeratin 5 & 6 is a useful immunohistochemical marker in the identification of mesothelioma and lung squamous cell carcinoma.1

Qualité

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Liaison

Cytokeratin 5 & 6 Positive Control Slides, Product No. 356S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris buffer, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

R Lersch et al.
Molecular and cellular biology, 9(9), 3685-3697 (1989-09-01)
The mitotically active basal layers of most stratified squamous epithelia express 10 to 30% of their total protein as keratin. The two keratins specifically expressed in these cells are the type II keratin K5 (58 kilodaltons) and its corresponding partner
Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas.
Ordo?ez, N.G.
Modern Pathology, 15, 6-10 (2002)
K Takahashi et al.
The Journal of biological chemistry, 270(31), 18581-18592 (1995-08-04)
The human type II keratin 6 (K6; 56 kDa) is expressed in a heterogeneous array of epithelial tissues under normal conditions, but is better known for its strong induction in stratified epithelia that feature an enhanced cell proliferation rate or
N G Ordóñez
The American journal of surgical pathology, 22(10), 1215-1221 (1998-10-20)
The immunohistochemical diagnosis of mesothelioma is commonly made by using a battery of antibodies that reacts with lung adenocarcinomas but not with epithelial mesotheliomas. Only recently have markers that are often expressed in mesotheliomas but not in adenocarcinomas been recognized.

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