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31404

Sigma-Aldrich

Sulfate de dextran sodium salt from Leuconostoc spp.

Mr 5,000

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About This Item

Numéro CAS:
9011-18-1
Numéro MDL:
MFCD00081551
Code UNSPSC :
12161700
Nomenclature NACRES :
NA.21

Source biologique

(Leuconostoc spp.)

Niveau de qualité

200

Forme

powder

Poids mol.

Mr 5,000

Composition

Sulfur Content, 16.0-20.0%

Perte

≤10% loss on drying

Plage de pH utile

6.0-8.0 (10 g/L)

Solubilité

H2O: 0.1 g/mL, clear, colorless to slightly yellow
water: 100 g/L at 25 °C (77 °F )
H2O: freely soluble 50 mg/mL, clear

Température de stockage

room temp

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Catégories apparentées

Application

Dextran sulfate sodium salt from Leuconostoc sp. is a polyanion used as a test reagent for testing its capability to rupture the extracellular enveloped virus (EEV) outer membrane. It has also been used for assessing the impact of TLR4 monoclonal antibody on the growth of dextran-sulfate-sodium-(DSS)-induced colitis.

Actions biochimiques/physiologiques

Dextran is a mixture of glucose polymers of varying size and geometry.Dextran in the form of dextran sulphate sodium acts as an anticoagulant. Dextran interferes with blood clot formation by acting on blood coagulation factors and the function of platelets. It prolongs the time required for formation of the clot and decreases the maximum clot strength. The disturbance of homeostasis by dextran may cause increased bleeding, colitis and kidney failure.

Notes préparatoires

prepared from dextran with Mr ~5000

Autres remarques

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Yi Liu et al.
Journal of gastroenterology and hepatology, 25(1), 209-214 (2009-11-26)
Ulcerative colitis (UC) refers to a kind of inflammatory bowel disease, of which the accurate pathogenesis is not yet well understood. Recently, the toll-like receptor 4 (TLR4) and the TLR4 signaling pathway have been proved as playing an important role
Kim L Roberts et al.
The Journal of general virology, 90(Pt 7), 1582-1591 (2009-03-07)
The extracellular enveloped virus (EEV) form of vaccinia virus (VACV) is surrounded by two lipid envelopes. This presents a topological problem for virus entry into cells, because a classical fusion event would only release a virion surrounded by a single
Se Young Choi et al.
Journal of biomedicine & biotechnology, 2010, 943516-943516 (2010-03-20)
A total of 28 male BALB/c mice (average weight 20.7 +/- 1.6 g) were divided into 4 treatment groups and fed a commercial diet (A), a commercial diet + induced colitis by dextran sodium sulfate (DSS) (B), Inonotus obliquus (IO)
Lisa Nebelin Hvidt et al.
Danish medical journal, 59(11), A4531-A4531 (2012-11-23)
Synthetic colloids are frequently used in fluid resuscitation of septic patients. Despite this, little is known about the potential side effects including the risk of renal failure and bleeding. As practice has changed, we performed a before-and-after study of fluid
Prevention of venous thromboembolism.
G P Clagett et al.
Chest, 108(4 Suppl), 312S-334S (1995-10-01)
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Articles

FITC-labelled polysaccharides

Additional information about FITC-labelled polysaccarides including FITC-Dextran, FITC-DEAE-dextran (FDD), FITC-carboxymethyl-dextran (FCM-Dextran). This page discusses the impact of weight-average molecular weight on the respective molecule dimensions and other physical properties

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