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Key Documents

238M-9

Sigma-Aldrich

Chromogranin A (LK2H10) Mouse Monoclonal Antibody

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About This Item

Code UNSPSC :
12352200
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

LK2H10, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (238M-94)
vial of 0.5 mL concentrate (238M-95)
bottle of 1.0 mL predilute (238M-97)
vial of 1.0 mL concentrate (238M-96)
bottle of 7.0 mL predilute (238M-98)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotype

IgG1κ

Contrôle

pancreas

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

cytoplasmic

Informations sur le gène

human ... CHGA(1113)

Catégories apparentées

Description générale

Immunohistochemical methods have localized chromogranin in a wide variety of endocrine tissues including the pituitary, pancreas, hypothalamus, thymus, thyroid, intestine, and parathyroid. Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin. It is generally accepted that the co-expression of certain keratins and chromogranin mean neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

Qualité


IVD
IVD
IVD
RUO

Liaison

Chromogranin A Positive Control Slides, Product No. 238S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

R Fischer-Colbrie et al.
Neuroscience, 16(3), 547-555 (1985-11-01)
Bovine chromaffin granules contain two major families of acidic proteins, chromogranins A and B. The occurrence of these proteins in endocrine and nervous tissue was investigated by immunoblotting (one- and two-dimensional), and by immunohistochemistry. Immunoblotting revealed that in anterior hypophysis
S A Hearn
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 35(7), 795-801 (1987-07-01)
An antibody (LK2H10) to chromogranin A has been recommended for use in ultrastructural identification of neuroendocrine secretory granules. Previous studies have demonstrated immunoreactive chromogranin A in specimens prepared for electron microscopy by glutaraldehyde fixation only. In this study, the effect
A M Bofin et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 110(9), 658-664 (2003-01-17)
The aim of the study was to determine if, by means of tyramide signal amplification (TSA), the presence of chromogranin A (CgA)-positive tumour cells could be demonstrated in breast cancer cases found to be negative by conventional immunohistochemical staining. Sections
G Qvigstad et al.
The Histochemical journal, 32(9), 551-556 (2000-12-29)
Neuroendocrine cells are often disclosed in human gastric adenocarcinomas and may be recognised by their immunoreactivity towards chromogranin A. However, in dedifferentiated neuroendocrine tumour cells, the chromogranin A content may be reduced making it difficult to detect with conventional immunohistochemical
G J Kontochristopoulos et al.
Dermatology (Basel, Switzerland), 201(2), 123-126 (2000-10-29)
Although Merkel cell carcinoma (MCC) exhibits specific clinical and histologic features, differentiation from other cutaneous neoplasms, such as lymphoma, metastatic oat cell carcinoma and malignant melanoma (MM), may sometimes be difficult. The aim of our study was to immunohistochemically differentiate
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