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17793

Sigma-Aldrich

Quercetin 3-β-D-glucoside

≥90% (HPLC)

Synonyme(s) :

3,3′,4′,5,7-Pentahydroxyflavone 3-β-glucoside, Isoquercitrin

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About This Item

Formule empirique (notation de Hill):
C21H20O12
Numéro CAS:
482-35-9
Poids moléculaire :
464.38
Numéro Beilstein :
100989
Numéro MDL:
MFCD00017746
Code UNSPSC :
12352205
ID de substance PubChem :
57647673
Nomenclature NACRES :
NA.25

Niveau de qualité

100

Pureté

≥90% (HPLC)

Application(s)

metabolomics
vitamins, nutraceuticals, and natural products

Température de stockage

−20°C

Chaîne SMILES 

OC[C@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C21H20O12/c22-6-13-15(27)17(29)18(30)21(32-13)33-20-16(28)14-11(26)4-8(23)5-12(14)31-19(20)7-1-2-9(24)10(25)3-7/h1-5,13,15,17-18,21-27,29-30H,6H2/t13-,15-,17+,18-,21+/m1/s1

Clé InChI

OVSQVDMCBVZWGM-QSOFNFLRSA-N

Informations sur le gène

mouse ... Hexa(15211)

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Catégories apparentées

Description générale

Quercetin 3-β-D-glucoside (Q3G), also known as isoquercitrin, is one of the major glycosidic forms of quercetin. It is a mono-glucoside, first isolated from the seed pods of Cercis canadensis L., it is also found in various plants, vegetables, and fruits. Q3G has the basic chemical structure of a flavonoid, with a glucose molecule attached to the C-3 of quercetin.

Application

Quercetin 3-β-D-glucoside has been used:
  • as a dietary flavonoid supplement to check its binding capacity with human small ubiquitin-related modifier 1 (SUMO1) protein using surface plasmon resonance (SPR)
  • as an inhibitor for Escherichia coli adenosine triphosphate (ATP) synthase
  • as an anti-aggregation agent to test its activity against β-amyloid, green fluorescent protein (GFP), and chymotrypsinogen proteins

Actions biochimiques/physiologiques

Quercetin 3-β-D-glucoside possesses strong antioxidant and anti-inflammatory activities. Being a potent oxygen-radical scavenger, it is a neuroprotective agent that improves Alzheimer′s disease (AD) condition in mice models. It has shown antiproliferative activity against colon, lung, and hepatocellular cell lines and MCF-7 human breast cancer cells in combination with apple extracts.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Quercitrin primary reference standard

00740580

Quercitrin

Quercetin 7-glucoside phyproof® Reference Substance

PHL82640

Quercetin 7-glucoside

Quercetin ≥95% (HPLC), solid

Sigma-Aldrich

Q4951

Quercetin

Quercitrin hydrate ≥78%

Sigma-Aldrich

Q3001

Quercitrin hydrate

Kaempferol 3-O-β -rutinoside ≥98.0% (HPLC)

Sigma-Aldrich

90242

Kaempferol 3-O-β -rutinoside

Hyperoside primary reference standard

00180585

Hyperoside

Prasanna K Dadi et al.
International journal of biological macromolecules, 45(1), 72-79 (2009-04-21)
We have studied the inhibitory effect of five polyphenols namely, resveratrol, piceatannol, quercetin, quercetrin, and quercetin-3-beta-D glucoside on Escherichia coli ATP synthase. Recently published X-ray crystal structures of bovine mitochondrial ATP synthase inhibited by resveratrol, piceatannol, and quercetin, suggest that
Jun Yang et al.
Journal of agricultural and food chemistry, 57(18), 8581-8586 (2009-08-22)
Breast cancer is the most frequently diagnosed cancer in women. An alternative strategy to reduce the risk of cancer is through dietary modification. Although phytochemicals naturally occur as complex mixtures, little information is available regarding possible additive, synergistic, or antagonistic
Zhongxiang Zhao et al.
Journal of natural products, 70(10), 1683-1686 (2007-10-10)
Five new flavan-4-ol glycosides, abacopterins E-I ( 5- 9), and seven known flavonoid glycosides ( 3 and 10- 15) were isolated from the aerial parts of the fern Abacopteris penangiana. Their structures were elucidated on the basis of extensive spectroscopic
Teresa Mencherini et al.
Journal of natural products, 73(2), 247-251 (2010-01-12)
Three new saponins (1-3) and a known saponin, together with four known polyphenolic compounds, have been isolated from the fermented and dried leaves of Fadogia ancylantha (Makoni tea). The structures of compounds 1-3 were established by analysis of their spectroscopic
Mahendra Thapa et al.
Bioorganic & medicinal chemistry letters, 22(1), 353-356 (2011-11-26)
Influenza viruses are important pathogens that cause respiratory infections in humans and animals. In addition to vaccination, antiviral drugs against influenza virus play a significant role in controlling viral infections by reducing disease progression and virus transmission. Plant derived polyphenols
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