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Key Documents

Y0000769

Promethazine impurity D

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

(2RS)-N,N-Dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine S-oxide, Promethazine 5-sulfoxide

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About This Item

Formule empirique (notation de Hill):
C17H20N2OS
Numéro CAS:
7640-51-9
Poids moléculaire :
300.42
Code UNSPSC :
41116107
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

promethazine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Température de stockage

2-8°C

InChI

1S/C17H20N2OS/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)21(20)17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

Clé InChI

OWTCLFIFAFHQIX-UHFFFAOYSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Promethazine impurity D EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0000797

Promethazine hydrochloride, European Pharmacopoeia (EP) Reference Standard

P3400000

Promethazine hydrochloride, European Pharmacopoeia (EP) Reference Standard

PHR1467

Promethazine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material

1570009

Promethazine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1570029

Promethazine Related Compound B, United States Pharmacopeia (USP) Reference Standard

BP412

Promethazine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP778

Isopromethazine hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP505

Promethazine sulfoxide, British Pharmacopoeia (BP) Reference Standard

PHR2777

Promethazine Related Compound B, Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 50 mg

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

L Galzigna et al.
Free radical biology & medicine, 20(6), 807-811 (1996-01-01)
Promethazine sulfoxide was obtained with a quantitative yield in a horse radish peroxidase-catalyzed reaction of promethazine and hydrogen peroxide and was also prepared by direct chemical synthesis. The enzymatic sulfoxidation of promethazine was studied in vitro as a function of
L Galzigna et al.
Free radical research, 27(5), 501-504 (1998-03-28)
Lactoperoxidase, when incubated with increasing amounts of promethazine (P) and promethazine sulfoxide (PO) catalyzes the formation of promethazine sulfoxide accompanied by oxygen consumption. An intermediate radical of PO can be detected by electron spin resonance (ESR). Catalase or superoxide dismutase
Ronald J Peters et al.
Journal of drug education, 33(4), 415-425 (2004-07-09)
In the current study, we used a qualitative approach to investigate relevant beliefs and norms associated with codeine and promethazine hydrochloride cough syrup (CPHCS) consumption, initiation, and perceived addiction among 48 alternative school students who identified themselves as current CPHCS
S R Vanapalli et al.
Journal of chromatographic science, 39(2), 70-72 (2001-03-14)
A new assay method has been developed for the quantitation of promethazine (PMZ) with a sensitivity and reproducibility as good as any previously reported method. This method is also capable of quantitatively determining three metabolites of PMZ (monodemethylated, sulphoxidated, and
Xufei Li et al.
Se pu = Chinese journal of chromatography, 30(9), 938-942 (2013-01-05)
Based on the phenomenon that each of chlorpromazine (CPZ), promethazine (PMZ), chlorpromazine sulfoxide (CPZSO) and promethazine sulfoxide (PMZSO) could enhance the electrochemiluminescence (ECL) intensity of tris(2,2'-bipyridyl) ruthenium, a novel and sensitive method was proposed for the simultaneous determination of CPZ

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