SMB00947

N-Desethyl amodiaquine dihydrochloride

≥95%

• Synonyme(s) : Monodesethylamodiaquine dihydrochloride
• Formule empirique (notation de Hill): C₁₈H₁₈ClN₃O · 2HCl
• Numéro CAS: 79049-30-2
• Poids moléculaire : 400.73
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic
• Niveau de qualité: 200
• Pureté: ≥95%
• Forme: solid
• Poids mol.: 400.73 g/mol
• Technique(s): HPLC: suitable
• Couleur: yellow to dark yellow
• Solubilité: DMSO: soluble; methanol: soluble; water: soluble
• Température de stockage: 2-8°C

Description

Application

Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.

Metabolomics research

Autres remarques

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable