55697

5-Hydroxyindole-3-acetic acid

analytical standard

• Synonyme(s) : 5-HIAA
• Formule empirique (notation de Hill): C₁₀H₉NO₃
• Numéro CAS: 54-16-0
• Poids moléculaire : 191.18
• Numéro Beilstein : 168797
• Numéro MDL: MFCD00005639
• Code UNSPSC : 41116107
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: analytical standard
• Pureté: ≥98% (HPLC); ≥98% (T)
• Durée de conservation: limited shelf life, expiry date on the label
• Pf: 161-164 °C (dec.) (lit.)
• Application(s): clinical testing
• Format: neat
• Température de stockage: −20°C
• Chaîne SMILES: OC(=O)Cc1c[nH]c2ccc(O)cc12
• InChI: 1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
• Clé InChI: DUUGKQCEGZLZNO-UHFFFAOYSA-N

Description

Application

• 5-HIAA assay development: Recent advancements include the use of 5-Hydroxyindole-3-acetic acid (5-HIAA) in assay kits aimed at measuring serotonin metabolites accurately, crucial for diagnosing and monitoring treatment outcomes in disorders like carcinoid syndrome. This assay is essential in neurochemistry for evaluating neurotransmitter pathways and their dysregulation (Zhou et al., 2021).


• Neurotransmitter metabolism studies: 5-HIAA is extensively used in research to understand serotonin′s metabolic pathways, offering insights into its role in neurological disorders such as depression and anxiety. This research supports the development of targeted therapies by mapping neurotransmitter fluctuations and interactions (Wang et al., 2024).


• Neurochemical analysis in Parkinson′s disease: Utilizing 5-HIAA, researchers have developed models to explore neurotransmitter dysfunction in Parkinson′s disease, aiding in the understanding of its pathophysiology and contributing to better therapeutic approaches (Couvillion et al., 2023).


• Serotonin degradation studies: 5-HIAA is critical in studying serotonin degradation. This research uses 5-HIAA to quantify serotonin levels and its metabolic effects on the central nervous system (Zhu et al., 2023).


• Development of fluorescent biosensors: Research includes the use of 5-HIAA in the development of novel fluorescent biosensors for detecting serotonin and its metabolites, which are vital for real-time monitoring of these neurochemicals in various biological settings (Zheng et al., 2022).

Actions biochimiques/physiologiques

Major serotonin metabolite.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable