MABT166
Anti-Tom20/Tomm20 Antibody, clone 2F8.1
clone 2F8.1, from mouse
Synonyme(s) :
Mitochondrial import receptor subunit TOM20 homolog, Mitochondrial 20 kDa outer membrane protein, Outer mitochondrial membrane receptor Tom20, TOM20, TOMM20
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified antibody
Type de produit anticorps
primary antibodies
Clone
2F8.1, monoclonal
Espèces réactives
human, mouse
Technique(s)
immunocytochemistry: suitable
western blot: suitable
Isotype
IgG1κ
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TOMM20(9804)
Description générale
Mitochondrial import receptor subunit TOM20 homolog (TOM20 or TOMM20), also known as mitochondrial 20 kDa outer membrane protein or outer mitochondrial membrane receptor Tom20, is a central component of the pre-protein translocase complex of the outer mitochondrial membrane (TOM complex) which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial pre-proteins. The TOM complex consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). TOM20 interacts with TOM22 and facilitates the movement of pre-proteins into the TOM40 translocation pore. Also interacts with APEX1.
Immunogène
GST-tagged recombinant protein corresponding to human Tom20/Tomm20.
Application
Anti-Tom20/Tomm20, clone 2F8.1 detects levels of Tom20/Tomm20 proteins & has been published & validated for use in WB & ICC.
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Tom20/Tomm20 in A431, NIH/3T3, and HeLa cells.
Research Category
Cell Structure
Cell Structure
Research Sub Category
Adhesion (CAMs)
Adhesion (CAMs)
Qualité
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected Tom20/Tomm20 in 200 µg of HeLa cell lysate.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected Tom20/Tomm20 in 200 µg of HeLa cell lysate.
Description de la cible
~ 16 kDa observed
Forme physique
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Remarque sur l'analyse
Control
HeLa cell lysate
HeLa cell lysate
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Réf. du produit
Description
Tarif
Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Renu A Kowluru et al.
Antioxidants (Basel, Switzerland), 11(2) (2022-02-26)
Diabetic patients routinely have elevated homocysteine levels, and due to increase in oxidative stress, hyperhomocysteinemia is associated with increased mitochondrial damage. Mitochondrial homeostasis is directly related to the balance between their fission and fusion, and in diabetes this balance is
Ghulam Mohammad et al.
Journal of diabetes research, 2022, 3555889-3555889 (2022-04-12)
Mitochondria play a central role in the development of diabetic retinopathy and in the metabolic memory associated with its continued progression. Mitochondria have a regulated fusion fission process, which is essential for their homeostasis. One of the major fission proteins
Jun Wei et al.
Nature, 576(7787), 471-476 (2019-12-13)
Adoptive cell therapy represents a new paradigm in cancer immunotherapy, but it can be limited by the poor persistence and function of transferred T cells1. Here we use an in vivo pooled CRISPR-Cas9 mutagenesis screening approach to demonstrate that, by
Lingxin Zhu et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 38(2), 335-353 (2022-12-12)
Signal transducer and activator of transcription 3 (STAT3), a cytokine-responsive transcription factor, is known to play a role in immunity and bone remodeling. However, whether and how STAT3 impacts macrophage NLR family pyrin domain containing 3 (NLRP3) inflammasome activation associated
Chi G Weindel et al.
eLife, 9 (2020-02-15)
The Parkinson's disease (PD)-associated gene leucine-rich repeat kinase 2 (LRRK2) has been studied extensively in the brain. However, several studies have established that mutations in LRRK2 confer susceptibility to mycobacterial infection, suggesting LRRK2 also controls immunity. We demonstrate that loss
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