MABF270
Anti-STING Antibody, clone S17G2C4B7
clone S17G2C4B7, from mouse
Synonyme(s) :
Stimulator of interferon genes protein, Endoplasmic reticulum interferon stimulator, ERIS, hMITA, hSTING, Mediator of IRF3 activation, Transmembrane protein 173
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Niveau de qualité
Forme d'anticorps
purified antibody
Type de produit anticorps
primary antibodies
Clone
S17G2C4B7, monoclonal
Espèces réactives
mouse, human
Technique(s)
immunocytochemistry: suitable
western blot: suitable
Isotype
IgG1κ
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... TMEM173(340061)
Description générale
Stimulator of interferon genes protein (UniProt Q86WV6; also known as Endoplasmic reticulum interferon stimulator, ERIS, hMITA, hSTING, Mediator of IRF3 activation, Transmembrane protein 173) is encoded by the TMEM173 (also known as ERIS, MITA, MPYS, SAVI, STING) gene (Gene ID 340061) in human. STING is an adaptor protein activated by cytosolic dsDNA or cyclic dinucleotides and plays a critical role in initiating innate responses to infection by various pathogens, including Herpes simplex virus (HSV). Once activated, STING translocates to the endoplasmic reticulum and activates the TBK1/IRF3 pathway that in turn mediates the upregulation of interferon (IFN) β. In addition, the DNA sensor IFI16 is also known to function as a STING ligand and potentiates STING-dependent sensing of viral infection by presenting cellular viral DNA to STING. STING is a four transmembrane (a.a. 21-41, 47-67, 87-106, 116-136) protein with both its N- and C-terminal ends exposed intracellularly (a.a. 1-20 and 137-379).The C-terminal cytoplasmic tail contains the c-di-GMP-binding domain (CBD; a.a. 153-340) with two c-di-GMP-binding regions (a.a. 162-167 & 238-241).
Spécificité
Clone S17G2C4B7 recognizes an epitope in the C-terminal cytoplasmic domain of human and murine STING.
Immunogène
Epitope: Amino acids 301-315.
His-tagged recombinant human STING C-terminal cytoplasmic domain fragment.
Application
Anti-STING Antibody, clone S17G2C4B7 is an antibody against STING for use in Western Blotting, Immunocytochemistry.
Research Category
Inflammation & Immunology
Inflammation & Immunology
Research Sub Category
Infectious Diseases - Viral
Infectious Diseases - Viral
Western Blotting Analysis: A 1:200 dilution from a representative lot detected the expression of exogenously transfected human and murine STING in HEK293T cells, as well as the endogenous STING in telomerase-immortalized human foreskin fibroblasts hTERT-BJ1 (Courtesy of Dr. Glen N. Barber, University of Miami School of Medicine, FL, U.S.A.).
Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected the expression of exogenously transfected human and murine STING in HEK293T cells, as well as the endogenous STING in telomerase-immortalized human foreskin fibroblasts hTERT-BJ1 (Courtesy of Dr. Glen N. Barber, University of Miami School of Medicine, FL, U.S.A.).
Immunocytochemistry Analysis: A 1:50 dilution from a representative lot detected the expression of exogenously transfected human and murine STING in HEK293T cells, as well as the endogenous STING in telomerase-immortalized human foreskin fibroblasts hTERT-BJ1 (Courtesy of Dr. Glen N. Barber, University of Miami School of Medicine, FL, U.S.A.).
Qualité
Evaluated by Western Blotting in HEK293T cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected STING in 50 µg of HEK293T cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected STING in 50 µg of HEK293T cell lysate.
Description de la cible
~38 kDa observed. 42.19 kDa calculated.
Forme physique
Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Autres remarques
Concentration: Please refer to lot specific datasheet.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
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Tanusree Sen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(2), 424-446 (2019-11-07)
Persistent endoplasmic reticulum (ER) stress in neurons is associated with activation of inflammatory cells and subsequent neuroinflammation following traumatic brain injury (TBI); however, the underlying mechanism remains elusive. We found that induction of neuronal-ER stress, which was mostly characterized by
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