MABE959

Anti-MBNL2 Antibody, clone MB2a(3B4)

clone MB2a(3B4), 1 mg/mL, from mouse

• Synonyme(s) : Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, Muscleblind-like protein-like 39
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: MB2a(3B4), monoclonal
• Espèces réactives: mouse
• Réactivité de l'espèce (prédite par homologie): human (based on 100% sequence homology)
• Concentration: 1 mg/mL
• Technique(s): western blot: suitable
• Isotype: IgG2bκ
• Numéro d'accès NCBI: NP_659002
• Numéro d'accès UniProt: Q5VZF2
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... MBNL2(10150)

Description

Description générale

MBNL2, also known as Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, or Muscleblind-like protein-like 39, and encoded by the gene MBNL2/MBLL/MBLL39/MLP1, is a protein that mediates pre-mRNA alternative splicing regulation. MBNL2 acts either as an activator or repressor of splicing on specific pre-mRNA targets. For instance MBNL2 inhibits cardiac troponin-T pre-mRNA exon inclusion but induces insulin receptor pre-mRNA exon inclusion in muscle. MBNL2 may also regulate ITGA3 expression by transporting it from the nucleus to cytoplasm at adhesion plaques. MBNL2 appears to play a key role in the muscle disease named myotonic dystrophy pathophysiology. MBNL2 is expressed in the nucleus of cells in multiple tissues but can be found in the cytoplasm in certain situations. In particular it is found in the cytoplasm in adhesion plaques.

Immunogène

Recombinant protein corresponding to human MBNL2.

Application

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

This Anti-MBNL2 Antibody, clone MB2a(3B4) is validated for use in Western Blotting for the detection of MBNL2.

Qualité

Evaluated by Western Blotting in C2C12 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected MBNL2 in 10 µg of C2C12 cell lysate.

Description de la cible

~40 kDa observed

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable