MABE270

Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1

clone 19E2.1, from mouse

• Synonyme(s) : Signal transducer and activator of transcription 6, IL-4 Stat
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 19E2.1, monoclonal
• Espèces réactives: human, mouse
• Technique(s): flow cytometry: suitable; western blot: suitable
• Isotype: IgG2aκ
• Numéro d'accès NCBI: NP_001171549
• Numéro d'accès UniProt: P42226
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: phosphorylation (pTyr641)
• Informations sur le gène: human ... STAT6(6778)

Description

Description générale

Signal transducer and activator of transcription 6 (STAT6) transduces signals from extracellular cytokines during adaptive immunity and has recently been found to be important in the innate immune response to viral infection. STAT6 is also involved in the attenuation of the Th1 and Th17 in the nephritogenic immune response. The consequence of STAT6 activity has been associated with the pathogenesis of autoimmune disease and has been found to be actively imported to the nucleus.

Spécificité

This antibody recognizes STAT6 phosphorylated at (Tyr641).

Immunogène

Epitope: Phosphorylated (Tyr641)

KLH-conjugated linear peptide corresponding to human STAT6 phosphorylated at (Tyr641).

Application

Anti-phospho STAT6 (Tyr641) Antibody, clone 19E2.1 is a mouse monoclonal antibody for detection of phospho STAT6 (Tyr641) also known as Signal transducer & activator of transcription 6, IL-4 Stat & has been validated in WB, FC.

Flow Cytometry Analysis: 2 µg/mL from a representative lot detected STAT6 in human peripheral blood leukocytes.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Transcription Factors

Qualité

Evaluated by Western Blot in NIH/3T3 cell lysates treated and untreated with PDGF.

Western Blot Analysis: 0.5 µg/mL of this antibody detected STAT6 on 10 µg of PDGF untreated and treated NIH/3T3 cell lysates.

Description de la cible

~165 kDa observed

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
NIH/3T3 cell lysates treated and untreated with PDGF

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable