MABC1151

Anti-NY-ESO-1 Antibody, clone D8.38

clone D8.38, from mouse

• Synonyme(s) : Cancer/testis antigen 1, Autoimmunogenic cancer/testis antigen NY-ESO-1, Cancer/testis antigen 6.1, CT6.1, L antigen family member 2, LAGE-2
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified antibody
• Type de produit anticorps: primary antibodies
• Clone: D8.38, monoclonal
• Espèces réactives: human
• Technique(s): immunohistochemistry: suitable (paraffin)
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_001318.1; NP_758965.2
• Numéro d'accès UniProt: O75638; P78358
• Conditions d'expédition: ambient
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CTAG1A(246100)

Description

Description générale

Cancer/testis antigen 1 (UniProt: P78358; also known as Autoimmunogenic cancer/testis antigen NY-ESO-1, Cancer/testis antigen 6.1, CT6.1, L antigen family member 2, LAGE-2) is encoded by the CTAG1A (also known as CTAG, CTAG1, ESO1, LAGE2, LAGE2A, CTAG1B, LAGE2B) gene (Gene ID: 1485; 246100) in human. NY-ESO-1 is a human tumor antigen of the cancer/testis family that is highly expressed in many poor-prognosis melanomas and in other cancer types. However, it is not detected in non-malignant tissues with the exception of germ cells and trophoblasts. It contains a C-terminal hydrophobic tail that potentially serves as membrane-associated domain. NY-ESO-1 is expressed from 18 weeks until birth in human fetal testis and in adult testis it is strongly expressed in spermatogonia and in primary spermatocytes, but not in post-meiotic cells or in testicular somatic cells. Although the exact function of NY-ESO-1 is still not clear, it has been speculated it might contribute to certain properties, such as immortality, self-renewal, migratory ability, and capacity to invade that favor tumor cell survival. On the basis of its immunogenicity, NY-ESO-1 is considered as one of the most attractive antigens for cancer immunotherapy. T cells engineered to express an affinity-enhanced T cell receptor (TCR) recognizing a naturally processed peptide shared by the cancer-testis antigens NY-ESO-1 and LAGE-1 have been considered as an attractive method for treatment of myeloma and enhance long-term survival of cells.

Spécificité

Clone D8.38 specifically targets a sequence in the N-terminal region and detects Cancer/testis antigen 1 (NY-ESO1) in human testis

Immunogène

A full length recombinant human NY-ESO-1 protein.

Epitope: domain of:

Application

Detect NY-ESO-1, LAGE-1 using this mouse monoclonal Anti-NY-ESO-1 antibody, clone D8.38, Cat. No. MABC1151. Validated for use in Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:250-1,000 dilution from a representative lot detected NY-ESO-1 in human testis tissue.

Immunohistochemistry Analysis: A representative lot detected NY-ESO-1 in Immunohistochemistry applications. (Yakirevich, E., et. al. (2003). Clin Cancer Res. 9(17):6453-60; Bujas, T., et. al. (2011). Eur J Histochem. 55(1):e7; Bolli, M., et. al. (2005). Int J Cancer. 115(6):960-6; Groeper, C., et. al. (2007). Int J Cancer. 120(2):337-43).

Research Category
Apoptosis & Cancer

Qualité

Evaluated by Immunohistochemistry in human testis tissue.

Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected NY-ESO-1 in human testis tissue.

Description de la cible

17.99 kDa calculated.

Forme physique

Format: Purified

Protein G purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1