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Principaux documents

MAB2008

Sigma-Aldrich

Anti-Integrin β3 Antibody, clone SAP

clone SAP, Chemicon®, from mouse

Synonyme(s) :

CD61

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

SAP, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Chemicon®

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable

Isotype

IgG1κ

Numéro d'accès NCBI

Numéro d'accès UniProt

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ITGB3(3690)

Spécificité

Monoclonal antibody MAB2008 is specific for the beta-3 subunit of the vitronectin receptor (VNR)J, which is expressed on endothelial cells, platelets, melanoma, and glioma cells. The antibody is of high affinity.

Immunogène

Membranes of freshly isolated human platelets.

Application

Detect Integrin β3 using this Anti-Integrin β3 Antibody, clone SAP validated for use in WB, IH, IH(P).
Immunohistochemistry (frozen and fixed tissue sections) including paraffin embedded sections. {See Van Belle et al 1999, original paper detailing the use in human, paraffin tissues}

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10333228.

Western blot: recognizes ~115kDa band in reduced

Optimal working dilutions must be determined by end user.

Forme physique

Format: Purified
Purified immunoglobulin. Liquid at 1 mg/mL in 0.02M phosphate buffer, 0.25M sodium chloride, pH 7.6, containing 0.1% sodium azide as a preservative.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer.
Jin Ju Kim,Jong-Tae Kim,Hyo Ran Yoon,Min Ah Kang,Joo Heon Kim,Young-Ha Lee,Jae Wha Kim et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine null
G Gruber et al.
British journal of cancer, 92(1), 41-46 (2004-12-15)
Integrins are cell-surface receptors, which mediate cell-to-cell and cell-to-extracellular matrix adhesion. Besides playing an important role in tumour angiogenesis, beta3-integrin is also expressed in several types of epithelial cancer cells. It was the purpose of the present study to evaluate
Expression and activation of alpha v beta 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells.
Yan-Xi Sun,Ming Fang,Jianhua Wang,Carlton R Cooper,Kenneth J Pienta,Russell S Taichman
Prostate null
P A Van Belle et al.
Human pathology, 30(5), 562-567 (1999-05-20)
The expression of the beta3 integrin subunit was investigated in 130 fixed, paraffin-embedded specimens of human melanomas and nevi using two different monoclonal antibodies. Expression was not observed in melanocytes and was absent or low in most nevi. In primary
Renée DuQuesnay et al.
Fertility and sterility, 91(2), 489-499 (2008-03-21)
To characterize possible endometrial defects in infertile women with isolated PCO morphology. Prospective study. An academic hospital with an IVF unit. Women with primary unexplained infertility and isolated PCO, fertile women, and women with infertility secondary to male factor. Thirty-one

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