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Key Documents

MAB1964

Sigma-Aldrich

Anti-Integrin β4 Antibody, clone 3E1

ascites fluid, clone 3E1, Chemicon®

Synonyme(s) :

CD104

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Forme d'anticorps

ascites fluid

Type de produit anticorps

primary antibodies

Clone

3E1, monoclonal

Espèces réactives

human

Fabricant/nom de marque

Chemicon®

Technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

Isotype

IgG1

Numéro d'accès NCBI

NM_000213.3
NM_001005619.1
NM_001005731.1

Numéro d'accès UniProt

P16144

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... ITGB4(3691)

Description générale

Integrin beta 4 is a glycoprotein which associates with the a6 integrin to form the a6/b4 complex. Integrin alpha 6/beta 4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Defects in Integrin beta 4 gene are a cause of epidermolysis bullosa letalis with pyloric atresia (EB PA); also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus. Moreover, defects in Integrin beta 4 gene are a cause of generalized atrophic benign epidermolysis bullosa (GABEB). This nonlethal form of junctional epidermolysis bullosa is characterized by life long blistering of the skin, associated with hair and tooth abnormalities.

Spécificité

Reacts with Human beta4 integrin. The antigen is present on epithelial cells.

Application

Stains human skin in immunofluorescence at approximately 1:200; acetone fixation required.

Also suitable for use in immunoprecipitation and flow cytometric assays.

Optimal working dilutions must be determined by the end user.
This Anti-Integrin β4 Antibody, clone 3E1 is validated for use in FC, IC, IH, IP for the detection of Integrin β4.

Forme physique

UnPurified ascites containing no preservatives.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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International journal of oncology, 21, 135-144 (2002)
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Hessle, H. et al.
Differentiation, 26, 49-54 (1984)
Rachel M Levine et al.
Bioengineering & translational medicine, 1(2), 168-180 (2016-08-08)
The greatest obstacle to clinical application of cancer gene therapy is lack of effective delivery tools. Gene delivery vehicles must protect against degradation, avoid immunogenic effects and prevent off target delivery which can cause harmful side effects. PEGylated liposomes have
Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity.
A Chen, I Cuevas, PA Kenny, H Miyake, K Mace, C Ghajar, A Boudreau, M Bissell, N Boudreau
Cancer Research null
Isolation, immortalization, and characterization of a human breast epithelial cell line with stem cell properties.
Gudjonsson, T; Villadsen, R; Nielsen, HL; R?nnov-Jessen, L; Bissell, MJ; Petersen, OW
Genes & Development null
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