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MAB1676

Sigma-Aldrich

Anti-Talin 1 Antibody, NT, a.a. 139-433, clone TA205

clone TA205, Chemicon®, from mouse

Synonyme(s) :

Anti-ILWEQ, Anti-TLN, Anti-talin-1

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

TA205, monoclonal

Espèces réactives

rabbit, human

Ne doit pas réagir avec

mouse, rat

Fabricant/nom de marque

Chemicon®

Technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

NM_006289.2

Numéro d'accès UniProt

Q9Y490

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TLN1(7094)

Spécificité

Human Talin. This antibody reacts with an N-terminal epitope in talin, between amino acids 139-433. On microinjection into whole cells MAB1676 disrupts actin stress fibers and focal contacts and inhibits cell motility.

Immunogène

Epitope: N-terminus, a.a. 139-433

Application

Anti-Talin 1 Antibody, N-terminus, a.a. 139-433, clone TA205 detects level of Talin & has been published & validated for use in IP, WB, IH.
Immunoblotting, recognizes a band at ~230kDa.

Immunoprecipitation

Immunofluorescence

Optimal working dilutions must be determined by end user.

Forme physique

Format: Purified
Liquid in 0.02 M PB pH 7.6, 0.25 M NaCl containing 0.1% sodium azide.

Stockage et stabilité

Maintain between 2 and 8°C for up to six months.

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

D C Love et al.
Experimental parasitology, 88(3), 161-171 (1998-04-30)
In the present study, we examine the cell biology of Leishmania amastigote uptake by mammalian cells and compare this process to the phagocytosis of IgG-opsonized erythrocytes. We report that many aspects of amastigote uptake into macrophages resemble classical receptor-mediated phagocytosis.
Trop-2 inhibits prostate cancer cell adhesion to fibronectin through the ?1 integrin-RACK1 axis.
Trerotola, M; Li, J; Alberti, S; Languino, LR
Journal of Cellular Physiology null
Li-Ting Su et al.
The Journal of biological chemistry, 281(16), 11260-11270 (2006-01-27)
m-Calpain is a protease implicated in the control of cell adhesion through focal adhesion disassembly. The mechanism by which the enzyme is spatially and temporally controlled is not well understood, particularly because the dependence of calpain on calcium exceeds the
S J Bolton et al.
Cell motility and the cytoskeleton, 36(4), 363-376 (1997-01-01)
We have characterized a panel of 6 monoclonal antibodies raised against human platelet talin by Western blotting, immune precipitation, and immunofluorescence, and shown that antibodies TA205 and TD77 disrupt actin stress fibers and focal adhesions, and inhibit cell motility when
Jaron Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(35), E4864-E4873 (2015-08-19)
Insight into how molecular machines perform their biological functions depends on knowledge of the spatial organization of the components, their connectivity, geometry, and organizational hierarchy. However, these parameters are difficult to determine in multicomponent assemblies such as integrin-based focal adhesions
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