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MAB1645

Sigma-Aldrich

Anti-Dystrophin Antibody, clone 1808

clone 1808, Chemicon®, from mouse

Synonyme(s) :

Anti-BMD, Anti-CMD3B, Anti-DXS142, Anti-DXS164, Anti-DXS206, Anti-DXS230, Anti-DXS239, Anti-DXS268, Anti-DXS269, Anti-DXS270, Anti-DXS272, Anti-MRX85

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

mouse

Niveau de qualité

100

Forme d'anticorps

purified antibody

Type de produit anticorps

primary antibodies

Clone

1808, monoclonal

Espèces réactives

chicken, mouse, rat, human

Fabricant/nom de marque

Chemicon®

Technique(s)

immunohistochemistry: suitable
western blot: suitable

Isotype

IgG1

Numéro d'accès NCBI

NM_000109.2
NM_004006.1
NM_004007.1
NM_004009.2
NM_004010.2
NM_004011.2
NM_004012.2
NM_004013.1
NM_004014.1
NM_004015.1
NM_004016.1
NM_004017.1
NM_004018.1
NM_004019.2
NM_004020.1
NM_004021.1
NM_004022.1
NM_004023.1

Numéro d'accès UniProt

P11532

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... DMD(1756)

Spécificité

By Western blot MAB1645 recognizes a single protein having a relative molecular weight of 300 kD. Reacts to mammalian skeletal muscle dystrophin. Shows no staining of mdx mouse muscle. Labels normal human muscle but not Duchenne muscle.

STAINING PATTERN:

On cryostat sections of normal mouse diaphragm MAB1645 gives strong immunofluorescence staining of the entire sarcolemma, with particularly strong staining of neuromuscular junctions.

SPECIES REACTIVITY:

Labels skeletal muscle from rat, chicken and Xenopus laevis. Labels cardiac muscle from rat and normal, but not mdx, mouse. Also labels smooth muscle from chicken gizzard.

Immunogène

Peripheral membrane proteins extracted from Torpedo postsynaptic membranes.

Application

Anti-Dystrophin Antibody, clone 1808 detects level of Dystrophin & has been published & validated for use in WB, IH.
Western blot

Immunohistochemistry

Optimal working dilutions must be determined by the end user.

Forme physique

Format: Purified
Liquid in 0.02 M phosphate buffer (pH 7.6), 250 mM NaCl with 0.1% sodium azide.

Stockage et stabilité

Maintain at -20ºC for up to 12 months in convenient aliquots. Avoid repeated freeze/thaw cycles.

Informations légales

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Peripheral proteins of postsynaptic membranes from Torpedo electric organ identified with monoclonal antibodies.
Froehner, S C
The Journal of cell biology, 99, 88-96 (1984)
S H Gee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(1), 128-137 (1998-01-24)
Syntrophins are cytoplasmic peripheral membrane proteins of the dystrophin-associated protein complex (DAPC). Three syntrophin isoforms, alpha1, beta1, and beta2, are encoded by distinct genes. Each contains two pleckstrin homology (PH) domains, a syntrophin-unique (SU) domain, and a PDZ domain. The
Andreas Schaefer et al.
Scientific reports, 9(1), 5710-5710 (2019-04-07)
Mechanical unloading (MU) by implantation of left ventricular assist devices (LVAD) has become clinical routine. This procedure has been shown to reverse cardiac pathological remodeling, with the underlying molecular mechanisms incompletely understood. Most studies thus far were performed in non-standardized
Dystrophin in a membrane skeletal network: localization and comparison to other proteins.
Dmytrenko, G M, et al.
The Journal of Neuroscience, 13, 547-558 (1993)
Localization of dystrophin relative to acetylcholine receptor domains in electric tissue and adult and cultured skeletal muscle.
Sealock, R, et al.
The Journal of cell biology, 113, 1133-1144 (1991)
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