869001-M

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

• Synonyme(s) : Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, Follitropin, hFSH
• Numéro CAS: 9002-68-0
• Numéro MDL: MFCD00131099
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human pituitary glands
• Niveau de qualité: 200
• Stérilité: non-sterile
• Gamme de produits: Calbiochem^®
• Pureté: ≥90%
• Forme: lyophilized solid
• Activité spécifique: ≥2000 IU/mg
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze
• Impuretés: ≤0.1% hCG; ≤0.5% hLH, hTSH
• pl: 4.1
• Solubilité: PBS: soluble
• Température de stockage: −20°C

Description

Description générale

Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland. FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.

Research area: Cell Signaling

Actions biochimiques/physiologiques

Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals. It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR) that is located on the granulosa cells of the ovaries and Sertoli cells of the testes. FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males. The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.

Avertissement

Toxicity: Carcinogenic / Teratogenic (D)

Notes préparatoires

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Costrici, N., et al. 1995. Endocrinology136, 4705.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable