420355

Isoprenaline hydrochloride

≥99% (TLC), solid, β-adrenoceptor agonist, Calbiochem

• Synonyme(s) : Isoproterenol, Hydrochloride
• Formule empirique (notation de Hill): C₁₁H₁₇NO₃ · xHCl
• Numéro CAS: 51-30-9
• Poids moléculaire : 211.26 (free base basis)
• Numéro MDL: MFCD00012603
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• product name: Isoproterenol, Hydrochloride, Phenethylamine derivative.
• Niveau de qualité: 100
• Pureté: ≥99% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: white to off-white; white
• Solubilité: ethanol: soluble; water: soluble
• Conditions d'expédition: ambient
• Température de stockage: 10-30°C
• InChI: 1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
• Clé InChI: IROWCYIEJAOFOW-UHFFFAOYSA-N

Description

Description générale

Phenethylamine derivative. Selective β-adrenergic agonist that increases cytosolic cAMP. Promotes glycogen breakdown and causes bronchodilation. Increases Cl^- diffusion and potential difference in rabbit trachea cells through nitric oxide generation.

Phenethylamine derivative. Selective β-adrenergic agonist that stimulates adenylate cyclase activity. Promotes glycogen breakdown and causes bronchodilation. Increases Cl^– diffusion and potential difference in rabbit trachea cells through nitric oxide generation. Reported to activate MAP Kinase (ERK) by a Rap1 and B-Raf dependent process.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
β-adrenergic agonist

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Irritant (B)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Autres remarques

Schmitt, J.M., and Stork, P.J. 2000. J. Biol. Chem.275, 25342.
Carmena, M.J., et al. 1997. Prostate 33, 46.
Takemura, H., et al. 1995. J. Pharmacol. Exp. Ther. 274, 584.
Kishimoto, I., et al. 1994. J. Biol. Chem.269, 28300.
Macaulay, S.L., et al. 1994. Mol. Cell Biochem.141, 27.
Yashiro, K., et al. 1994. J. Biochem.115, 1040.
Ladenheim, R.G., et al. 1993. J. Neurochem.60, 260.
von Zastrow, M., et al. 1993. J. Biol. Chem.268, 763.
Mokhtari, A., et al. 1985. J. Cyclic Nucleotide Protein Phosphorylation Res.10, 213.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable