401098

Human IgA, Plasma

• Synonyme(s) : IgA serum, Plasma IgA
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥95% (SDS-PAGE)
• Niveau de qualité: 200
• Forme: liquid
• Contient: ≤0.1% sodium azide as preservative
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles
• Isotype: IgA
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified

Description

Description générale

Immunoglobulin A (IgA) is the most dominantly generated antibody isotype. They are majorly secreted in the intestinal mucosa. IgA is present in colostrum, serum, saliva, and nasal fluid. It exists in two isotypic forms namely: IgA1 and IgA2. It is generated as secretory IgA (sIgA) and serum IgA. Serum IgA is present in the dimeric form linked by disulfide bond with an additional J chain. sIgA occurs in a monomeric form with two heavy and two light chains.

Application

Human IgA, Plasma has been used in enzyme-linked immunosorbent assay (ELISA).

Actions biochimiques/physiologiques

Immunoglobulin A (IgA) initiates the alternative pathway of the complement system to elicit protective functions. It facilitates antibody-dependent cell-mediated cytotoxicity (ADCC) by attaching to leukocytes. This interaction boosts microbial destruction. IgA performances the first line of defense in antigen clearance. It avoids proteolysis and hinders the uptake of viral, bacterial, or antigen attachment. It lowers inflammation aroused by the classical pathway complement activation.

Conditionnement

Please refer to vial label for lot-specific concentration.

Avertissement

Toxicity: Standard Handling (A)

Forme physique

In 100 mM NaCl, 100 mM Tris-HCl, pH 8.0.

Notes préparatoires

Prepared from plasma that has been shown by certified tests to be nonreactive for HBsAg and for antibodies to HCV, HBc, HIV-1 and HIV-2.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Autres remarques

Variables associated with assay conditions will dictate the proper working dilution.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Ce produit, destiné à la recherche scientifique, est soumis à une réglementation spécifique en France, y compris pour les activités d′importation et d′exportation (Article L 1211-1 alinéa 2 du Code de la Santé Publique). L′acheteur (c′est-à-dire l′utilisateur FINAL) est tenu d′obtenir une autorisation d′importation auprès du ministère français de la recherche, mentionné à l′article L1245-5-1 II du Code de la Santé Publique. En commandant ce produit, vous confirmez détenir l′autorisation d′importation requise.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): nwg
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable