344220

Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴

The Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴ controls the biological activity of Formyl Peptide Receptor-Like 1.

• Synonyme(s) : Formyl Peptide Receptor-Like 1 Antagonist, WRW⁴, H₂N-WRWWWW-CONH₂, FPRL1 Antagonist, WRW⁴
• Formule empirique (notation de Hill): C₆₁H₆₅N₁₅O₆
• Poids moléculaire : 1104.27
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: lyophilized solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C

Description

Description générale

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with ligand-receptor interaction {IC₅₀ = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks ligand-mediated [Ca²⁺]_i increase, ERK activation, and chemotactic migration of FPRL1-expressing RBL-2H3 cells at a concentration of 10 µM. Also inhibits Aβ₄₂ peptide-induced superoxide generation and prevents its internalization in human macrophages.

A Trp-rich hexapeptide that acts as a potent and specific antagonist of Formyl Peptide Receptor-Like 1 (FPRL1)-mediated signaling. Shown to bind to FPRL1 and interfere with the ligand-receptor interaction {IC₅₀ = 230 nM for FPRL1 Agonist, WKYMVm (Cat. No. 344216)}. Completely blocks the ligand activated [Ca²⁺]_i increase, ERK activation and chemotactic migration of FPRL1-expressing RBL-2H3 cells at 10 µM. Further, inhibits Aβ₄₂ peptide-induced superoxide generation and prevents its internalization in human macrophages.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Formyl Peptide Receptor-Like 1 (FPRL1)

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 230 nM for FPRL1 Agonist

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Séquence

H-Trp-Arg-Trp-Trp-Trp-Trp-CONH₂

Forme physique

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Autres remarques

Bae, Y.S., et al. 2004. J. Immunol.173, 607.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable