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Key Documents

324410

Sigma-Aldrich

Dynasore

≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®

Synonyme(s) :

Dynamin Inhibitor I, Dynasore, 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin

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About This Item

Formule empirique (notation de Hill):
C18H14N2O4
Numéro CAS:
304448-55-3
Poids moléculaire :
322.31
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

product name

Dynamin Inhibitor I, Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
protect from light

Couleur

pale yellow

Solubilité

DMSO: 16 mg/mL

Conditions d'expédition

ambient

Température de stockage

2-8°C

InChI

1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

Clé InChI

SYNDQCRDGGCQRZ-VXLYETTFSA-N

Description générale

A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Environmental Hazard (N)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Young, A., et al. 2009. Biochem. J., In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955.
Macia. E., et al. 2006. Dev. Cell10, 839.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Elsa M Reyes-Reyes et al.
Methods in molecular biology (Clifton, N.J.), 2036, 173-186 (2019-08-15)
Oligonucleotides can be designed or evolved to bind to specific DNA, RNA, protein, or small molecule targets and thereby alter the biological function of the target. The therapeutic potential of oligonucleotides targeted to intracellular molecules will depend largely on their
Alba García-Fernández et al.
Pharmaceutics, 14(7) (2022-07-28)
In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of inflammation in diseases, the synergistic effect of nanoparticles for gene-editing/drug therapy
Lina Wang et al.
Immunity, 56(2), 272-288 (2023-02-02)
Self-nonself discrimination is vital for the immune system to mount responses against pathogens while maintaining tolerance toward the host and innocuous commensals during homeostasis. Here, we investigated how indiscriminate DNA sensors, such as cyclic GMP-AMP synthase (cGAS), make this self-nonself
Ying Liu et al.
Kidney diseases (Basel, Switzerland), 6(6), 422-433 (2020-12-15)
Levels of urinary microvesicles, which are increased during various kidney injuries, have diagnostic potential for renal diseases. However, the significance of urinary microvesicles as a renal disease indicator is dampened by the difficulty to ascertain their cell source. The aim
Annemiek Dickhout et al.
International journal of molecular sciences, 22(14) (2021-07-25)
The chemokines CCL5 and CXCL4 are deposited by platelets onto endothelial cells, inducing monocyte arrest. Here, the fate of CCL5 and CXCL4 after endothelial deposition was investigated. Human umbilical vein endothelial cells (HUVECs) and EA.hy926 cells were incubated with CCL5
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