207008

Calcineurin Substrate

An excellent peptide substrate for calcineurin.

• Synonyme(s) : Calcineurin Substrate, PP2B Substrate, RII Phosphopeptide, DLDVPIPGRFDRRVpSVAAE
• Formule empirique (notation de Hill): C₉₂H₁₅₁N₂₈O₃₂P
• Poids moléculaire : 2192.33
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: lyophilized
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Solubilité: water: 2 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C

Description

Description générale

An excellent peptide substrate for calcineurin (Protein Phosphatase 2B, PP2B, Cat. No. 539568). The sequence is derived from the PKA regulatory subunit type II (RII) and is phosphorylated on the Ser residue. Release of phosphate can be quantified colorimetrically using malachite green method.

An excellent peptide substrate for calcineurin (Protein Phosphatase 2B, PP2B; Cat. No. 539568). The sequence is derived from the PKA regulatory subunit type II (RII) and is phosphorylated on the Ser residue. Release of phosphate can be quantified colorimetrically using the malachite green method.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
Calcineurin (Protein Phosphatase 2B, PP2B)

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Séquence

H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser(PO₃H₂)-Val-Ala-Ala-Glu-OH

Forme physique

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Donella-Deana, A., et al. 1994. Eur. J. Biochem. 219, 109.
Enz, A., et al. 1994. Anal. Biochem. 216, 147.
Harder, K.W., et al. 1994. Biochem. J. 298, 395.
Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable