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124005

Sigma-Aldrich

Akt Inhibitor

The Akt Inhibitor controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonyme(s) :

Akt Inhibitor, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl- sn-glycerocarbonate, 1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate

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About This Item

Formule empirique (notation de Hill):
C30H58O10
Poids moléculaire :
578.78
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (NMR)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
desiccated (hygroscopic)

Couleur

white to off-white

Solubilité

DMSO: 200 mg/mL

Conditions d'expédition

ambient

Température de stockage

−20°C

Description générale

A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range.
A cell permeable, reversible, and substrate competitive phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1-10 µM range.

Actions biochimiques/physiologiques

Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 5.0 µM for Akt (PKB)

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 weeks at -20°C.
Use anhydrous DMSO for reconstitution.

Autres remarques

Hu, Y., et al. 2000 J. Med. Chem.43, 3045.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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