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Merck
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Key Documents

07-886

Sigma-Aldrich

Anti-phospho-PKR (Thr451) Antibody

Upstate®, from rabbit

Synonyme(s) :

EIF2AK2 (eukaryotic translation initiation factor 2-alpha kinase 2), EIF2AK1, MGC126524, PKR, PRKR

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

mouse, human

Fabricant/nom de marque

Upstate®

Technique(s)

western blot: suitable

Isotype

IgG

Numéro d'accès NCBI

NM_002759.1

Numéro d'accès UniProt

P19525

Conditions d'expédition

dry ice

Modification post-traductionnelle de la cible

phosphorylation (pThr451)

Informations sur le gène

human ... EIF2AK2(5610)
mouse ... Eif2Ak2(19106)

Spécificité

Recognizes phosphorylated PKR (Thr451)

Immunogène

Peptide corresponding to amino acid region encompassing the human phospho-PKR (Thr451)

Application

Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling
This Anti-phospho-PKR (Thr451) Antibody is validated for use in WB for the detection of phospho-PKR (Thr451).

Qualité

Routinely evaluated by immunoblot.

Description de la cible

68 kDa

Forme physique

100 µL of affinity purified rabbit polyclonal IgG in Dulbecco’s PBS, containing 1.0 mg/mL BSA, 0.05% sodium azide and 50% glycerol.
ImmunoAffinity Purified

Stockage et stabilité

Stable for 2 years at -20°C from date of shipment.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

P R Romano et al.
Molecular and cellular biology, 18(4), 2282-2297 (1998-04-07)
The human double-stranded RNA-dependent protein kinase (PKR) is an important component of the interferon response to virus infection. The activation of PKR is accompanied by autophosphorylation at multiple sites, including one in the N-terminal regulatory region (Thr-258) that is required
Mechanisms that lessen benefits of ?-secretase reduction in a mouse model of Alzheimer's disease.
Devi, L; Ohno, M
Translational Psychiatry null
Latha Devi et al.
PloS one, 8(10), e77335-e77335 (2013-10-23)
Emerging evidence suggests that dysregulated translation through phosphorylation of eukaryotic initiation factor-2α (eIF2α) may contribute to Alzheimer's disease (AD) and related memory impairments. However, the underlying mechanisms remain unclear. Here, we crossed knockout mice for an eIF2α kinase (GCN2: general
Wei Li et al.
Scientific reports, 8(1), 166-166 (2018-01-11)
Cytoplasmic membrane-bound connexin 43 (Cx43) proteins oligomerize into hexameric channels (hemichannels) that can sometimes dock with hemichannels on adjacent cells to form gap junctional (GJ) channels. However, the possible role of Cx43 hemichannels in sterile and infectious inflammatory diseases has
Bruna T Dias et al.
Frontiers in immunology, 13, 801182-801182 (2022-02-15)
Leishmania donovani is a protozoan parasite that causes visceral leishmaniasis, provoking liver and spleen tissue destruction that is lethal unless treated. The parasite replicates in macrophages and modulates host microbicidal responses. We have previously reported that neutrophil elastase (NE) is
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