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Merck
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Key Documents

07-794

Sigma-Aldrich

Anti-Rab13 Antibody

Upstate®, from rabbit

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About This Item

Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100

Forme d'anticorps

affinity purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

polyclonal

Produit purifié par

affinity chromatography

Espèces réactives

human, rat, mouse

Fabricant/nom de marque

Upstate®

Technique(s)

immunofluorescence: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Numéro d'accès NCBI

NP_002861

Numéro d'accès UniProt

P51153

Conditions d'expédition

wet ice

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... RAB13(5872)

Description générale

Rab proteins are members of the Ras superfamily of small G-Proteins. At least 60 isoforms have been identified. These GTPases are primarily involved in vesicle trafficking and it is believed that a different Rab protein may be needed for each step of the vesicular transport. It is thought Rab4 and Rab11 are involved in internalization, sorting, and transport to lysosomes or recycling, of several membrane proteins, including GPCRs, GLUT-4, Aquaporin-2, or the H+/K+ ATPase.

Spécificité

Recognizes Rab13

Immunogène

Sythnetic peptide of amno acids 129-148 of rat Rab13

Application

Detect Rab13 using this Anti-Rab13 Antibody validated for use in WB, IP & IF.
Immunofluorescence Staining:
Independent laboratory demonstrated this antibody worked in Immunofluorescence studies at a 1:100-1:500 dilution.

Immunoprecipitation (IP):
Independent laboratory demonstrated this antibody works in Immunoprecipitation.

Qualité

Western Blot Analysis:
This lot detected Rab13 at 1:1,000 (1g/mL) dilution in lysates from PC12 lysate resolved via SDS-PAGE and transferred to PVDF (Immobilon-P).

Description de la cible

25 kDa

Forme physique

Affinity Purified rabbit IgG in storage buffer containing tri-citrate-phosphate, pH 7-8 and 0.1% sodium azide.

Informations légales

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Katja Köhler et al.
The Journal of cell biology, 165(2), 175-180 (2004-04-21)
The GTPase Rab13 regulates the assembly of functional epithelial tight junctions (TJs) through a yet unknown mechanism. Here, we show that expression of the GTP-bound form of Rab13 inhibits PKA-dependent phosphorylation and TJ recruitment of the vasodilator-stimulated phosphoprotein, an actin
I Kanda et al.
Oncogene, 27(12), 1687-1695 (2007-09-25)
Epithelial cell scattering recapitulates the first steps of carcinoma invasion/metastasis. While the balance between cell-cell adhesive activity and cell motility ultimately determines this process, its molecular mechanisms remain unclear. Adherence junctions and tight junctions (TJs) are primarily responsible for cell-cell
Shinya Morimoto et al.
The Journal of biological chemistry, 280(3), 2220-2228 (2004-11-06)
During epithelial morphogenesis, adherens junctions (AJs) and tight junctions (TJs) undergo dynamic reorganization, whereas epithelial polarity is transiently lost and reestablished. Although ARF6-mediated endocytic recycling of E-cadherin has been characterized and implicated in the rapid remodeling of AJs, the molecular
Simone Di Giovanni et al.
The Journal of biological chemistry, 280(3), 2084-2091 (2004-11-04)
Following spinal cord injury, there are numerous changes in gene expression that appear to contribute to either neurodegeneration or reparative processes. We utilized high density oligonucleotide microarrays to examine temporal gene profile changes after spinal cord injury in rats with

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