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800715P

Avanti

N-P Serine PA

Avanti Research™ - A Croda Brand 800715P, powder

Synonyme(s) :

N-palmitoyl-serine phosphoric acid (ammonium salt)

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About This Item

Formule empirique (notation de Hill) :
C19H44N3O7P
Numéro CAS:
799268-44-3
Poids moléculaire :
457.54
Numéro MDL:
MFCD00056438
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Essai

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 1 mg (800715P-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 800715P

Type de lipide

phosphoglycerides

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

Lysophosphatidic acid (LPA) receptor modulators include N-palmitoyl serine phosphoric acid and N-palmitoyl-tyrosine phosphoric acid. N-palmitoyl serine phosphoric acid is a competitive inhibitor of the LPA receptor in Xenopus oocytes. However, in mammalian cells, N-palmitoyl-serine phosphoric acid may act as an agonist for the LPA receptor. LPA is a lipid mediator that acts similar to growth factors through G-protein coupled plasma membrane receptors. LPA may play a role in platelet aggregation, smooth muscle contraction, vasoactive changes, cytoskeletal reorganization and cell proliferation. N-palmitoyl serine phosphoric acid may also play a role in signal transduction in mammalian cells by increasing intracellular calcium.
N-palmitoyl serine phosphoric acid prevents human platelet aggregation, which is induced by 1-hexadecyl-2-lyso-sn-glycero-3-phosphate.

Conditionnement

5 mL Amber Glass Screw Cap Vial (800715P-1mg)

Notes préparatoires

Product use: A range of 0.1-20 mM of N-palmitoyl serine phosphoric acid can be used for cell studies. Make a stock solution of 5 mM in DMSO and store at -20°C. Diluted N-palmitoyl serine phosphoric acid can be directly added to the study medium. An et al. dissolved N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acid in 0.1 mL PBS containing 0.1 mg/mL human serum albumin before adding to cells. In X. laevis studies, these LPA inhibitors were dissolved in DMSO at 1 mM and filtered through a 0.45 mM membrane filter before injection.

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

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Chung-Ren Jan et al.
Pharmacology & toxicology, 93(2), 71-76 (2003-08-06)
The effect of N-palmitoyl-L-serine phosphoric acid (L-NASPA), which has been used as an inhibitor of lysophosphatidic acid receptors, on intracellular Ca2+ concentration ([Ca2+]i) in human osteosarcoma MG63 cells was measured by using fura-2. L-NASPA (0.1-10 microM) caused a rapid and
Novel effect of N-palmitoyl-L-serine phosphoric acid on cytosolic Ca2+ levels in human osteoblasts
Jan, C.R
Pharmacology & Toxicology, 93, 71-76 (2003)
Characterization of a receptor subtype-selective lysophosphatidic acid mimetic
Hooks, S.B, et. al.
Molecular Pharmacology, 53, 188-194 (1998)
Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization.
An, S
Molecular Pharmacology, 54, 881-888 (1998)
Inhibitors of lipid phosphatidate receptors: N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids.
Bittman R, et al.
Journal of Lipid Research, 37(2), 391-398 (1996)
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