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791275P

Avanti

18:0 PE-DTPA (Gd)

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt), powder

Synonyme(s) :

1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt); DSPE-DTPA (Gd)

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About This Item

Formule empirique (notation de Hill):
C55H106GdN6O17P
Numéro CAS:
2260795-19-3
Poids moléculaire :
1311.68
Numéro MDL:
MFCD00066515
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Essai

>99% (TLC)

Forme

powder

Conditionnement

pkg of 1 × 5 mg (791275P-5mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 791275P

Conditions d'expédition

dry ice

Température de stockage

−20°C

Catégories apparentées

Description générale

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) are sparing soluble in alcohol and well soluble in a solvent mixture consisting of chloroform and methanol in the ratio of 4:1, v/v. 18:0 PE-DTPA (Gd) is a synthetic phospholipid derivative ethanolamine. The DTPA is attached to gadolinium ion.

Application

18:0 PE-DTPA (Gd) has been used:
  • as a component of Gadolinium-liposome preparation
  • in the nanodics preparation for nuclear magnetic resonance (NMR) studies
  • in construction of cysteine-arginine-glutamic acid-lysine alanine (CREKA) based peptide amphiphile micelles (PAMs) for the magnetic resonance imaging (MRI) studies
  • as a spin-labeled lipid for supported lipid bilayer incorporation for cryo transmission electron microscopy studies

Actions biochimiques/physiologiques

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-diethylenetriaminepentaacetic acid (gadolinium salt) (18:0 PE-DTPA (Gd)) phospholipid based liposomes are useful in magnetic resonance imaging (MRI) and multimodal imaging. Apart from being a MRI contrast agent, PE-DTPA (Gd) liposome is also flexible for modification for binding different targets using copper–free click–chemistry methodology.

Conditionnement

5 mL Amber Glass Screw Cap Vial (791275P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number

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Consulter la Bibliothèque de documents

Fibrin-targeting, peptide amphiphile micelles as contrast agents for molecular MRI
Chung EJ, et al.
journal of Cell Science & Therapy, 5(5), 1-1 (2014)
Supported Lipid Bilayers on Fluorescent Nanodiamonds: A Structurally Defined and Versatile Coating for Bioapplications
Vavra J, et al.
Advances in Functional Materials, 28(45), 1803406-1803406 (2018)
Jin Young Kang et al.
Immunity, 31(6), 873-884 (2009-11-26)
Toll-like receptor 2 (TLR2) initiates potent immune responses by recognizing diacylated and triacylated lipopeptides. Its ligand specificity is controlled by whether it heterodimerizes with TLR1 or TLR6. We have determined the crystal structures of TLR2-TLR6-diacylated lipopeptide, TLR2-lipoteichoic acid, and TLR2-PE-DTPA
Zhenhao Fang et al.
Cell chemical biology, 25(11), 1327-1336 (2018-08-21)
KRAS is frequently mutated in several of the most lethal types of cancer; however, the KRAS protein has proven a challenging drug target. K-RAS4B must be localized to the plasma membrane by prenylation to activate oncogenic signaling, thus we endeavored

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