700061P

24(S)-hydroxycholesterol

Avanti Research^™ - A Croda Brand

• Synonyme(s) : 5-cholestene-3β,24-diol; 24-hydroxycholest-5-en-3-ol
• Formule empirique (notation de Hill): C₂₇H₄₆O₂
• Numéro CAS: 474-73-7
• Poids moléculaire : 402.65
• Code UNSPSC : 12352211
• Nomenclature NACRES : NA.25

Propriétés

• Description: cholest-5-ene-3β,24(S)-diol
• Pureté: >99% (TLC)
• Forme: powder
• Conditionnement: pkg of 1 × 1 mg (700061P-1mg); pkg of 1 × 5 mg (700061P-5mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• InChI: 1S/C27H46O2/c1-17(2)25(29)11-6-18(3)22-9-10-23-21-8-7-19-16-20(28)12-14-26(19,4)24(21)13-15-27(22,23)5/h7,17-18,20-25,28-29H,6,8-16H2,1-5H3/t18-,20+,21+,22-,23+,24+,25+,26+,27-/m1/s1
• Clé InChI: IOWMKBFJCNLRTC-XWXSNNQWSA-N

Description

Description générale

24(S)-hydroxycholesterol (24HC) is synthesized from cholesterol in brain dendrites by the action of enzyme cholesterol 24-hydroxylase (CYP46A1). It is catabolized to bile acids in the liver.

Application

24(S)-hydroxycholesterol has been used as an internal standard:

• in ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS)
• in liquid chromatography with tandem mass spectrometry (LC-MS/MS) for the quantification of 27-hydroxycholesterol from colorectal tumor samples
• for quantification of human plasma sterols by liquid chromatography with tandem mass spectrometry (LC MS/MS)

Actions biochimiques/physiologiques

24(S)-hydroxycholesterol (24HC) elevated levels are reported in liver inflammation and fibrosis. It is a N-methyl-D-aspartate receptor (NMDAR) modulator. The levels of 24HC are potential indicators of brain development as well as pathology including Alzheimer′s disease (AD) and multiple sclerosis. Polymorphism in the cholesterol 24-hydroxylase (CYP46A1) gene leads to elevated 24HC levels and toxicity. 24HC is a mediator of apoptosis and necroptosis. Elevated levels of 24HC are reported in liver inflammation and fibrosis.

Conditionnement

5 mL Amber Glass Screw Cap Vial (700061P-1mg)

5 mL Amber Glass Screw Cap Vial (700061P-5mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable