700053P

25-hydroxycholesterol-d6

Avanti Research^™ - A Croda Brand

• Synonyme(s) : 26,26,26,27,27,27-hexadeuterocholest-5-ene-3β,25-diol; 25-hydroxycholest-5-en-3-ol(d6)
• Formule empirique (notation de Hill): C₂₇H₄₀D₆O₂
• Numéro CAS: 88247-69-2
• Poids moléculaire : 408.69
• Numéro MDL: MFCD00201435
• Code UNSPSC : 41141804
• Nomenclature NACRES : NA.25

Propriétés

• Description: cholest-5-ene-3β,25-diol-d6
• Essai: >99% (TLC)
• Forme: powder
• Conditionnement: pkg of 1 × 1 mg (700053P-1mg)
• Fabricant/nom de marque: Avanti Research^™ - A Croda Brand
• Conditions d'expédition: dry ice
• Température de stockage: −20°C

Description

Description générale

25-hydroxycholesterol (25HC) is synthesized from cholesterol in the presence of oxygen and enzyme cholesterol 25-hydroxylase and the conversion is dependent on nicotinamide adenine dinucleotide phosphate (NADPH) during toll-like receptor activation. 25HC is catabolized to 7α-hydroxylated sterol. 25-hydroxycholesterol-d6 is the deuterated form of 25-hydroxycholesterol.

Application

25-hydroxycholesterol-d6 has been used as an internal standard:

• in the quantification of 25-OHC in jejunum samples by liquid chromatography with tandem mass spectrometry (LC-MS-MS)
• in plasma samples by liquid chromatography-mass spectrometry analysis
• for calibration curve generation for plasma oxysterol quantification

Actions biochimiques/physiologiques

25-hydroxycholesterol is a liver X receptor ligand. This bioactive lipid regulates immune response and macrophages production from monocytes. 25-HC serves as an antiviral effector and may have therapeutic potential. It reduces cholesterol biosynthesis by inactivating sterol regulatory element binding protein and inhibits HMG-CoA reductase (HMGCR). 25-HC may play a protective role in myocardial ischemia-reperfusion injury by inhibiting apoptosis and regulating mitogen-activated protein kinase (MAPK) pathway.

Conditionnement

5 mL Amber Glass Screw Cap Vial (700053P-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Point d'éclair (°F): No data available
• Point d'éclair (°C): No data available