Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

934216

Sigma-Aldrich

NanoFabTx™ - Mannose Lipid Mix

for synthesis of mannose-targeted liposomes

Synonyme(s) :

Liposome synthesis kit, Small molecule drug formulation kit

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
12352211

Niveau de qualité

100

Température de stockage

−20°C

Application

NanoFabTx™ Mannose Lipid Mix is a ready-to-use curated lipid mixture containing rationally selected lipids and step by step instructions for synthesizing mannose targeted liposomes.Mannose receptors are over expressed on several cancer cells. Mannose receptors are also over expressed by macrophages, which play a critical role in inflammatory responses. Thus the mannose receptor can be used to achieve targeted delivery of drugs to these cells. The liposomes containing the mannose ligand will be internalized by the cells that over express the mannose receptors. Such a delivery technique will help in achieving targeted delivery of the drugs and avoid off target effects, which is a major side effect of many cancer therapies.

The mannose targeted- liposomes synthesized from the NanoFabTx™ Mannose Lipid Mix enable users to 1) encapsulate a wide variety of small molecules and 2) selectively target cells which overexpress mannose receptors, such as macrophages and certain cancer cells, without the need for lengthy trial-and-error optimization.

Caractéristiques et avantages

  • A ready-to-use lipid blend for the synthesis of Mannose targeted liposomes
  • Step-by-step protocols (extrusion, microfluidics) developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Mannose ligand enables targeted drug delivery
Comprehensive protocols for liposome synthesis are included:
  • A lipid film hydration and extrusion protocol
  • A microfluidics protocol using commercial platforms or syringe pumps
The microfluidics protocol included with this product uses the NanoFabTx™ device kit (911593). These kits come with the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

For more information, please refer to the protocol under the Protocol section of this page.

Informations légales

NanoFabTx is a trademark of Sigma-Aldrich Co. LLC
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

Si vous avez besoin d'assistance, veuillez contacter Service Clients

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique