Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

View All Documentation

933546

Sigma-Aldrich

NanoFabTx™ - Natural Folate Lipid Mix

for synthesis of folate functionalized liposomes for targeted delivery

Synonyme(s) :

Cholesterol, EggPC, Folate-PEG-DSPE, PE-PEG

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(1)

About This Item

Code UNSPSC :
12352211
Nomenclature NACRES :
NA.21

Niveau de qualité

100

Température de stockage

−20°C

Application

NanoFabTx™ Natural Folate Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of folate-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of therapeutic drug molecules for targeted drug delivery applications without the need for lengthy trial-and-error optimization.
NanoFabTx™ Natural Folate Lipid Mix is a lyophilized, curated, lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve liposomes of approximately 100nm in diameter. The synthesized folate-functionalized liposomes can be used to selectively target cells which overexpress folate receptors such as HeLa cells and delivery hydrophilic or hydrophobic drugs, including therapeutics that are thermo-sensitive.

Caractéristiques et avantages

  • A ready-to-use nanoformulation lipid blend for the synthesis of folate-functionalized liposomes without the need for high temepratures
  • Step-by-step protocols developed and tested by our formulation scientists
  • Flexible synthesis tool to create uniform and reproducible liposomes
  • Optimized to make liposomes around 100 nm with low polydispersity
  • Optimized lipid blend for folate-functionalized liposomes for therapeutic encapsulation
For microfluidic liposome synthesis of azide-functionalized liposomes, the NanoFabTx™- Natural Folate Lipid Mix can be used with the the NanoFabTx™Microfluidic - nano device kit (Cat.No. 911593). The NanoFabTx™Microfluidic - nano device kit includes the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Informations légales

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

Désolés, nous n'avons pas de COA pour ce produit disponible en ligne pour le moment.

Si vous avez besoin d'assistance, veuillez contacter Service Clients

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Mahmoud M Omar et al.
International journal of nanomedicine, 16, 683-700 (2021-02-05)
To develop an externally triggered rapid-release targeted system for treating ovarian cancer, gemcitabine (GMC) was entrapped into sonosensitive (SoS) folate (Fo)-modified liposomes (LPs). GMC-loaded LPs (GMC LPs), GMC-loaded Fo-targeted LPs (GMC-Fo LPs), and GMC-loaded Fo-targeted SoS LPs (GMC-SoS Fo LPs)
Yan Tie et al.
Signal transduction and targeted therapy, 5(1), 6-6 (2020-04-17)
Tumor-associated macrophages (TAMs) facilitate cancer progression by promoting tumor invasion, angiogenesis, metastasis, inflammatory responses, and immunosuppression. Folate receptor β (FRβ) is overexpressed in TAMs. However, the clinical significance of FRβ-positive macrophages in lung cancer remains poorly understood. In this study

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique