920584

5-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazine-2-carboxylic acid

• Synonyme(s) : Rigid linker for PROTAC^® development
• Formule empirique (notation de Hill): C₁₃H₁₇N₃O₄
• Poids moléculaire : 279.29
• Numéro MDL: MFCD34602227
• Code UNSPSC : 12352106
• Nomenclature NACRES : NA.22

Propriétés

• Forme: powder
• Niveau de qualité: 100
• Pertinence de la réaction: reagent type: linker
• Groupe fonctionnel: Boc; carboxylic acid
• Température de stockage: 2-8°C
• Chaîne SMILES: CC(C)(OC(N1CC(C2=CN=C(C(O)=O)C=N2)C1)=O)C
• InChI: 1S/C13H17N3O4/c1-13(2,3)20-12(19)16-6-8(7-16)9-4-15-10(5-14-9)11(17)18/h4-5,8H,6-7H2,1-3H3,(H,17,18)
• Clé InChI: UMVYLQZBFNQMPM-UHFFFAOYSA-N

Description

Application

5-(1-(tert-Butoxycarbonyl)azetidin-3-yl)pyrazine-2-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.

Similar linkers in this series:
920487
920495
920576
ADV638390284

Autres remarques

Portal: Building PROTAC^® Degraders for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable