917478

BocA1V1PF2

≥95%

• Synonyme(s) : (S)-2-((S)-1-((S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)-3,3-dimethylbutanoyl)pyrrolidine-2-carboxamido)-3-(4-fluorophenyl)propanoic acid, AVP ligand, IAP E3 ligase lead for protein degrader research, SNIPER building block
• Formule empirique (notation de Hill): C₂₈H₄₁FN₄O₇
• Poids moléculaire : 564.65
• Code UNSPSC : 41116105
• Nomenclature NACRES : NA.22

Propriétés

• ligand: BocA1V1PF2
• Niveau de qualité: 100
• Pureté: ≥95%
• Forme: powder
• Pertinence de la réaction: reagent type: ligand
• Groupe fonctionnel: carboxylic acid
• Température de stockage: 2-8°C
• Chaîne SMILES: C[C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(O)=O)CC2=CC=C(C=C2)F)=O)=O)C(C)(C)C)=O

Description

Application

BocA1V1PF2 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. A C-terminal variant of BocA1V1PF2 is also available as A1V1PF2-OEt (917710).

BocA1V1PF2 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC^® degrader libraries: Degrader Building Blocks
916927 BocA1V1PF2-OC₆-NH₂ hydrochloride
917184 BocA1V1PF2-OC₁₀-NH₂ hydrochloride
917435 BocA1V1PF2-OPEG₁-NH₂ hydrochloride
917680 BocA1V1PF2-OPEG₃-NH₂ hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

Autres remarques

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable