902578

Hydroxy-PEG6-t-butyl ester

≥95%

• Synonyme(s) : tert-Butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate, HO-PEG6-CO-OtBu
• Formule empirique (notation de Hill) : C₁₉H₃₈O₉
• Numéro CAS: 361189-64-2
• Poids moléculaire : 410.50
• Numéro MDL: MFCD13185017
• Code UNSPSC : 51171641
• Nomenclature NACRES : NA.22

Propriétés

• Essai: ≥95%
• Forme: liquid
• Pertinence de la réaction: reagent type: cross-linking reagent
• Indice de réfraction: n/D 1.454
• Densité: 1.068
• Groupe fonctionnel: ester; hydroxyl
• Température de stockage: −20°C
• Chaîne SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOCCOCCOCCO
• InChI: 1S/C19H38O9/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h20H,4-17H2,1-3H3
• Clé InChI: VGGDPFAYSOSIOK-UHFFFAOYSA-N

Description

Application

This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or roteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Autres remarques

Synthesis and Molecular Recognition Studies of the HNK-1 Trisaccharide and Related Oligosaccharides. The Specificity of Monoclonal Anti-HNK-1 Antibodies as Assessed by Surface Plasmon Resonance and STD NMR

Maleimide-oligo(ethylene glycol) Derivatives of Camptothecin as Albumin-Binding Prodrugs: Synthesis and Antitumor Efficacy

Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable