688495

(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline

97%

• Synonyme(s) : (4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole
• Formule empirique (notation de Hill): C₂₅H₂₆NOP
• Numéro CAS: 148461-16-9
• Poids moléculaire : 387.45
• Numéro MDL: MFCD09998277
• Code UNSPSC : 12352005
• ID de substance PubChem : 329761168
• Nomenclature NACRES : NA.22

Propriétés

• Pureté: 97%
• Forme: solid
• Activité optique: [α]22/D -57.0°, c = 1 in chloroform
• Pf: 111-116 °C
• Température de stockage: −20°C
• Chaîne SMILES: CC(C)(C)[C@@H]1N=C(C2=CC=CC=C2P(C3=CC=CC=C3)C4=CC=CC=C4)OC1
• InChI: 1S/C25H26NOP/c1-25(2,3)23-18-27-24(26-23)21-16-10-11-17-22(21)28(19-12-6-4-7-13-19)20-14-8-5-9-15-20/h4-17,23H,18H2,1-3H3/t23-/m1/s1
• Clé InChI: DMOLTNKQLUAXPI-HSZRJFAPSA-N

Description

Description générale

The product is a phosphinooxazoline (PHOX) ligand introduced by Pfaltz and coworkers. These non-symmetrical modular P,N-ligands are particularly useful in cases where double bond migration leads to undesired products or mixtures of isomers.

Application

(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline can be used as a ligand for enantioselective Heck reaction without any C=C double bond migration byproduct. It can also be used in a rhodium(I)-catalyzed enantioselective desymmetrization reaction of meso-3,5-dimethyl glutaric anhydride, to form substituted syn-deoxypolypropionate fragments in a single transformation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)