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Sigma-Aldrich

Poly(ethylene glycol) diglycidyl ether

average MN 500, cross-linking reagent amine reactive, glycidyl

Synonyme(s) :

Polyethylene glycol, Diepoxy PEG, PEG diglycidyl ether, Polyoxyethylene bis(glycidyl ether)

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About This Item

Formule linéaire :
C3H5O2-(C2H4O)n-C3H5O
Numéro CAS:
Numéro MDL:
Code UNSPSC :
12162002
Nomenclature NACRES :
NA.23

Nom du produit

Poly(ethylene glycol) diglycidyl ether, average Mn 500

Poids mol.

average Mn 500

Pertinence de la réaction

reagent type: cross-linking reagent
reactivity: amine reactive

Indice de réfraction

n20/D 1.47

Extrémité Ω

epoxy

Extrémité α

epoxy

Architecture des polymères

shape: linear
functionality: homobifunctional

Température de stockage

2-8°C

Chaîne SMILES 

O1C(C1)COCCOCC2OC2

InChI

1S/C8H14O4/c1(9-3-7-5-11-7)2-10-4-8-6-12-8/h7-8H,1-6H2

Clé InChI

AOBIOSPNXBMOAT-UHFFFAOYSA-N

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Description générale

Poly(ethylene glycol) diglycidyl ether (PEGDGE) shows highly solubility in water. Hence, it easily undergoes hydrolysis followed by ring cleavage reaction in aqueous solution, yielding hydroxyl group. PEGDGE combines with proteins covalently or non-covalently. PEGDGE is widely used in chemical industries for cross linking and surface modifier.

Application

The high solubility of PEGDGE has been successfully employed to immobilize glucose oxidase, d-amino acid oxidase and glutamate oxidase. It may be used as a component for the development of microelectrode biosensors to detect hydrogen peroxide and nitric oxide.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

386.6 °F - closed cup

Point d'éclair (°C)

197.00 °C - closed cup

Équipement de protection individuelle

Eyeshields, Gloves


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Articles

Patterning of PEG-based Hydrogels - Engineering Spatial Complexity

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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