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Merck

SCN5A

sodium channel, voltage-gated, type V, alpha subunit

Synonymes:
CDCD2, CMD1E, CMPD2, HB1, HB2, HBBD, HH1, ICCD, IVF, LQT3, Nav1.5, PFHB1, SSS1, VF1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(6331) Summary: The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Mouse(20271) sodium channel, voltage-gated, type V, alpha
  • Rat(25665) sodium channel, voltage-gated, type V, alpha subunit
  • chicken(395947) sodium channel, voltage-gated, type V, alpha subunit
  • domestic cat(101100994) sodium channel, voltage-gated, type V, alpha subunit
  • Horse(100034027) sodium channel, voltage-gated, type V, alpha subunit
  • dog(403497) sodium channel, voltage-gated, type V, alpha subunit
  • domestic guinea pig(100723340) sodium channel, voltage-gated, type V, alpha subunit
  • naked mole-rat(101710111) sodium channel, voltage-gated, type V, alpha subunit
  • Domestic Rabbit(100009516) sodium channel, voltage-gated, type V, alpha subunit
  • cow(282061) sodium channel, voltage-gated, type V, alpha subunit
  • sheep(101111582) sodium channel, voltage-gated, type V, alpha subunit

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-Sodium Channel NaV1.5 human antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
human
Application
western blot
Anti-Sodium Channel Nav1.5 Antibody, pain, Chemicon®, from rabbit,
Espèces réactives
rat
Application
western blot
Anti-SCN5A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
Anti-SCN5A antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
Anti-SCN5A (C-terminal) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, canine, guinea pig, horse, human, mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
Flecainide acetate salt, ,
Espèce(s)
human
(±)-Flecainide solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Flecainide acetate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Flecainide acetate, European Pharmacopoeia (EP) Reference Standard,
Espèce(s)
human
Flecainide acetate, British Pharmacopoeia (BP) Reference Standard,
Espèce(s)
human

Small Molecule - Ligand

Référence du produit
Description
Espèce(s)
Lamotrigine, ≥98%, powder,
Espèce(s)
rat, human
Carbamazepine, powder,
Espèce(s)
rat, human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human SCN5A,
Espèce(s)
human