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Merck

GRM6

glutamate receptor, metabotropic 6

Synonymes:
CSNB1B, GPRC1F, MGLUR6, mGlu6
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(2916) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]
  • Mouse(108072) glutamate receptor, metabotropic 6
  • Rat(24419) glutamate receptor, metabotropic 6
  • dog(481452) glutamate receptor, metabotropic 6
  • cow(529656) glutamate receptor, metabotropic 6
  • domestic cat(101097449) glutamate receptor, metabotropic 6
  • domestic guinea pig(100722389) glutamate receptor, metabotropic 6
  • naked mole-rat(101717017) glutamate receptor, metabotropic 6

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
D-2-Aminoadipic acid, ,
Espèce(s)
rat
L-2-Aminoadipic acid, ≥98% (TLC),
Espèce(s)
rat, human
trans-(±)-ACPD monohydrate, solid, ≥97% (NMR),
Espèce(s)
human
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Espèce(s)
rat, human
(S)-AMPA, ≥97%,
Espèce(s)
mouse, human, rat

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
D-2-Aminoadipic acid, ,
Espèce(s)
rat
DL-2-Amino-3-phosphonopropionic acid, ,
Espèce(s)
human
(S)-AMPA, ≥97%,
Espèce(s)
mouse, human, rat
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Espèce(s)
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espèce(s)
rat, human

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-MGLUR6 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunohistochemistry

western blot
Anti-GRM6 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
immunohistochemistry
Monoclonal Anti-GRM6 antibody produced in mouse, clone 1A11, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
Anti-GRM6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunohistochemistry

Small Molecule - Mixed Agonist/Antagonist

Référence du produit
Description
Espèce(s)
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Espèce(s)
rat, human
L-Glutamic acid, ReagentPlus®, ≥99% (HPLC),
Espèce(s)
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espèce(s)
rat, human
L-Glutamic acid, BioUltra, ≥99.5% (NT),
Espèce(s)
rat, human
L-Glutamic acid, FCC,
Espèce(s)
rat, human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human GRM6,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Grm6,
Espèce(s)
mouse