GRIA2
glutamate receptor, ionotropic, AMPA 2
Synonymes:
GLUR2, GLURB, GluA2, GluR-K2, HBGR2
Espèce(s):
Human GRIA2 (2891), Mouse Gria2 (14800), Rat Gria2 (29627), chicken GRIA2 (414894), domestic cat GRIA2 (101088234), cow GRIA2 (614283), Horse GRIA2 (100069331), dog GRIA2 (482667), domestic guinea pig Gria2 (100379153), naked mole-rat Gria2 (101708417)
ID UniProtKB:
ID du gène:
- Human(2891) Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
- Mouse(14800) glutamate receptor, ionotropic, AMPA2 (alpha 2)
- Rat(29627) glutamate receptor, ionotropic, AMPA 2
- chicken(414894) glutamate receptor, ionotropic, AMPA 2
- domestic cat(101088234) glutamate receptor, ionotropic, AMPA 2
- cow(614283) glutamate receptor, ionotropic, AMPA 2
- Horse(100069331) glutamate receptor, ionotropic, AMPA 2
- dog(482667) glutamate receptor, ionotropic, AMPA 2
- domestic guinea pig(100379153) glutamate receptor, ionotropic, AMPA2 (alpha 2)
- naked mole-rat(101708417) glutamate receptor, ionotropic, AMPA 2
- sheep(443272) glutamate receptor, ionotropic, AMPA 2
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Small Molecule - Agonist
Référence du produit
Description
Espèce(s)
2,6-Difluoro-4-[2-(phenylsulfonylamino)ethylthio]phenoxyacetamide, ≥98% (HPLC), solid,
Espèce(s)
human
Small Molecule - Allosteric Modulator
Référence du produit
Description
Espèce(s)
Small Molecule - Antagonist
Référence du produit
Description
Espèce(s)
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anticorps anti-récepteur du glutamate 2 et 3, Chemicon®, from rabbit,
Espèces réactives
gerbil, guinea pig, hamster, human, monkey, mouse, rat
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anticorps anti-GluR2, from rabbit, purified by affinity chromatography,
Espèces réactives
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-GluR2 Antibody, clone 6C4, Alexa Fluor™ 488 Conjugate, clone 6C4, from mouse, ALEXA FLUOR™ 488,
Espèces réactives
mouse, rat
Application
immunocytochemistry
immunohistochemistry
immunohistochemistry
Anti-GluR2/3 Antibody, Upstate®, from rabbit,
Espèces réactives
chicken, human, monkey, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-GLUR2 pS880 (Clone 022.19.5) Antibody, clone 022.19.5, from mouse,
Espèces réactives
rat
Application
western blot
Small Molecule - Blocker
Référence du produit
Description
Espèce(s)
Topiramate solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
Small Molecule - Mixed Agonist/Antagonist
Référence du produit
Description
Espèce(s)
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Espèce(s)
rat, human
