1597005

Quinine sulfate

United States Pharmacopeia (USP) Reference Standard

• Synonym(s): Quinine hemisulfate salt monohydrate, Quinine sulfate (2:1) (salt) dihydrate
• Empirical Formula (Hill Notation): C₂₀H₂₄N₂O₂ · 0.5H₂O₄S · H₂O
• CAS Number: 207671-44-1
• Molecular Weight: 391.47
• Beilstein: 6113937
• MDL number: MFCD00150790
• UNSPSC Code: 41116107
• PubChem Substance ID: 329751013

Properties

• grade: pharmaceutical primary standard
• API family: quinine
• mol wt: monograph mol wt. 782.94 ((C₂₀H₂₄N₂O₂)₂ . H₂SO₄ . 2H₂O)
• manufacturer/tradename: USP
• mp: ~225 °C (dec.) (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5
• InChI: 1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1
• InChI key: ZHNFLHYOFXQIOW-LPYZJUEESA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Quinine sulfate is the sulfate salt of quinine, an alkaloid, obtained from the bark of Cinchona species.

Application

Quinine sulfate may be used as a pharmaceutical primary standard for the quantification of the analyte in pharmaceutical formulations using chromatography techniques.

Biochem/physiol Actions

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315 - H319 - H335
• Precautionary Statements: P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable