504955-30
Discovery® C18 (5 µm) HPLC Columns
L × I.D. 15 cm × 3 mm, HPLC Column
Synonym(s):
C18 TM=["Discovery"] HPLC Column
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About This Item
UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52
product name
Discovery® C18 HPLC Column, 5 μm particle size, L × I.D. 15 cm × 3 mm
material
stainless steel column
Agency
suitable for USP L1
product line
Discovery®
feature
endcapped
manufacturer/tradename
Discovery®
packaging
1 ea of
extent of labeling
12% Carbon loading
parameter
≤70 °C temp. range
400 bar pressure (5801 psi)
technique(s)
HPLC: suitable
LC/MS: suitable
L × I.D.
15 cm × 3 mm
surface area
300 m2/g
surface coverage
3 μmol/m2
impurities
<10 ppm metals
matrix
silica gel, high purity, spherical particle platform
fully porous particle
matrix active group
C18 (octadecyl) phase
particle size
5 μm
pore size
180 Å
operating pH range
2-8
application(s)
food and beverages
separation technique
reversed phase
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General description
Use Discovery® C18 for any method that specifies a C18. The exceptional peak shape, reproducibility, and stability make it the column of choice for all C18 methods from demanding to routine.
Application
- A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies.: This paper describes the use of the Discovery® C18 HPLC Column in developing a stability-indicating method for the COVID-19 therapeutic, molnupiravir, emphasizing its critical role in supporting pandemic response through advanced drug formulation and analysis (Recber et al., 2022).
- Features of assay and decomposition dynamics of 2-methoxy-4-(1-propenyl)hydroxybenzene in biological material.: Demonstrates the versatility of the Discovery® C18 HPLC Column in forensic science, particularly in the analysis and decomposition studies of complex organic compounds within biological samples (Chernova et al., 2022).
Features and Benefits
- Excellent reproducibility
- Exceptional peak shape for basic and acidic analytes
- Stable, low-bleed LC-MS separations
- Separation of peptides and small proteins
- Lower hydrophobicity than many comparable C18 columns, providing faster analysis
Legal Information
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
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T Nagano et al.
Journal of dental research, 88(9), 823-828 (2009-09-22)
Mmp-20 and Klk4 are the two key enamel proteases. Can both enzymes process amelogenin to generate the major cleavage products that accumulate during the secretory stage of amelogenesis? We isolated Mmp-20 and Klk4 from developing pig teeth and used them
Yuan-Qing Xia et al.
Rapid communications in mass spectrometry : RCM, 20(12), 1831-1837 (2006-05-18)
A major challenge in selecting an appropriate stationary phase for diastereomeric separation is that it is difficult to predict which of the commercially available stationary phases could achieve the required liquid chromatographic (LC) separation. This work describes the selection and
T R Shantha Kumar et al.
Journal of pharmaceutical and biomedical analysis, 38(1), 173-179 (2005-05-24)
A simple, precise and accurate isocratic reverse-phase liquid chromatography method with programmed wavelength detection has been validated to quantify DRF-4367 and Phenol red, simultaneously for application in rat in situ single pass intestinal perfusion study to assess intestinal permeability of
Satoru Sonoke et al.
Cancer research, 68(21), 8843-8851 (2008-11-01)
The pharmacokinetics and antitumor activity of pegylated small interfering RNA (siRNA)/cationic liposome complexes were studied after systemic administration to mice. We designed pegylated-lipid carriers for achieving increased plasma concentrations of RNA and hence improved accumulation of RNA in tumors by
Yoshinori Masukawa et al.
Journal of lipid research, 49(7), 1466-1476 (2008-03-25)
Ceramides (CERs) in human stratum corneum (SC) play physicochemical roles in determining barrier and water-holding functions of the skin, and specific species might be closely related to the regulation of keratinization, together with other CER-related lipids. Structures of those diverse
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