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Key Documents

SRP0426

Sigma-Aldrich

PDE1B active rat

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE)

Synonym(s):

PDE1B1, PDES1B, phosphodiesterase 1B, calmodulin-dependent

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

rat

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥70% (SDS-PAGE)

form

aqueous solution

mol wt

89 kDa

packaging

pkg of 10 μg

UniProt accession no.

Q01066

shipped in

dry ice

storage temp.

−70°C

Gene Information

rat ... PDE1B(5153)

General description

Rat PDE1B (GenBank Accession No. NM_022710) full length with N-terminal HIS-GST-tag, MW= 89kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Andrew T Bender et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(2), 460-465 (2006-01-13)
Monocyte-to-macrophage differentiation with the cytokine granulocyte-macrophage colony-stimulating factor induces expression of the cyclic nucleotide phosphodiesterase PDE1B2. However, what role PDE1B2 plays in macrophage biology has not been elucidated. We have addressed this question by inhibiting PDE1B2 induction by using RNA
Andrew T Bender et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(2), 497-502 (2004-12-31)
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a major regulator of monocyte to macrophage differentiation. In both humans and mice, the main phenotype of decreased GM-CSF function is pulmonary proteinosis due to aberrant function of alveolar macrophages. Recently, this cytokine has been

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