SML0279

LG100268

≥98% (HPLC)

• Synonym(s): 2-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]pyridine-5-carboxylic acid, AGN 192620, ALRT 268., CD 3127, LG268, LGD 100268, LGD 1268
• Empirical Formula (Hill Notation): C₂₄H₂₉NO₂
• CAS Number: 153559-76-3
• Molecular Weight: 363.49
• MDL number: MFCD01758574
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825287
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: ≥5 mg/mL (warmed)
• storage temp.: −20°C
• SMILES string: Cc1cc2c(cc1C3(CC3)c4ccc(cn4)C(O)=O)C(C)(C)CCC2(C)C
• InChI: 1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
• InChI key: SLXTWXQUEZSSTJ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

LG100268 (LG268) is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC₅₀ = 3-4 nM and has no activity at the RAR retinoic acid receptors.

Features and Benefits

This compound is featured on the Nuclear Receptors (Non-Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable